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An essential vasodilator with some anti-androgenic effects, has excellent safety record
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5 / 6 resultslearn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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Research
5 / 1000+ resultsresearch Multimodal Roles of Transient Receptor Potential Channel Activation in Inducing Pathological Tissue Scarification
Targeting TRP channels may help reduce excessive scarring.
research Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes
TRPV3 in skin cells causes inflammation and cell death.
research Mechanisms of Proton Inhibition and Sensitization of the Cation Channel TRPV3
Acid can block TRPV3 from outside the cell but boost its function from inside.
research The ATP Sensitive Potassium Channel (KATP) Is a Novel Target for Migraine Drug Development
Blocking the KATP channel may help treat migraines.
research Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxicity
Sodium metabisulfite increases sodium channel activity, leading to higher cell excitability and potential damage.
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5 / 443 resultscommunity Is this Better Than Topical Minoxidil? Topical Diazoxide
Topical diazoxide may be a promising hair regrowth treatment, especially for those who don't respond to minoxidil, as it activates potassium channels without needing sulfation. It appears safe for topical use, avoiding systemic effects seen in oral use.
community Creatine is the opposite of minoxidil !
Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.
community New & Improved Hair Growth Stack for Maximum Results
A user shared a hair growth stack using minoxidil sulfate, valproic acid, bimatoprost, blue copper peptide, and other ingredients, emphasizing a gel-based formula for better skin tolerance. Another user suggested adding a 5-alpha-reductase inhibitor like finasteride or dutasteride for more effective long-term results.
community 7 years on oral finasteride/topical minoxidil/ket (Pics included). Losing ground... what more can I do to stop the loss and gain more hair?
A user's journey to try and stop their hair loss, including the use of oral finasteride, topical minoxidil, ketoconazole shampoo, Cynatine Keratin supplements, and The Ordinary's Multi-Peptide Serum for Hair Density; and advice from other users regarding trying dutasteride, oral minoxidil, and lifestyle changes.
community REVOLUTION in AUGUST: New possibilities according to Dr. Muñoz (pinacidil, cromakalim, diazoxide and nicorandil)
Dr. Muñoz's discovery suggests that targeting potassium channels in fibroblasts could reactivate hair growth, offering new treatment possibilities for alopecia. Potential strategies include using minoxidil, diazoxide, and other potassium channel openers, as well as bioelectric devices and direct growth factor applications.