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research Association of fibrosis in the bulge portion with hair follicle miniaturization in androgenetic alopecia

February 2021 in “Journal of The American Academy of Dermatology”

This study observed that fibrosis occurs in the bulge region of hair follicles affected by androgenetic alopecia and is correlated with the hair miniaturization process.

research The supplemental materials of “Association of Fibrosis in Bulge Portion with Hair Follicle Miniaturization in Androgenetic Alopecia”.

January 2021

This document supplements a study on androgenetic alopecia, describing materials and methods, and includes figures showing fibrosis in the bulge region of miniaturized hair follicles.

research Sox13 is a novel early marker for hair follicle development

6 citations , January 2019 in “Biochemical and Biophysical Research Communications”

This study suggests that Sox13, although dispensable for epidermal development, serves as a marker for early hair follicle development in Sox13-LacZ knock-in mice.

research Morphometric Analysis of the Human Scalp Hair Follicle: Practical Implications for the Hair Transplant Surgeon and Hair Regeneration Studies

51 citations , November 2010 in “Dermatologic Surgery”

This study measured the lengths and depths of different portions of occipital scalp hair follicles and suggested cutting below 1 mm for hair regeneration procedures to avoid damaging the bulge zone.

research Epithelial stem cells and implications for wound repair

156 citations , October 2012 in “Seminars in Cell & Developmental Biology”

This study found that hair follicle stem cells initially contribute to wound re-epithelialization, but long-lasting epidermal cells are primarily derived from a stem cell population in the isthmus portion of hair follicles.

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community Hair cloning breakthrough, this might just be the big one ?

418 upvotes 6 months ago

Japanese scientists discovered ABM cells, enabling successful human hair follicle cloning, potentially curing hair loss. The treatment may be available in Japan by 2028, but it will be expensive and require travel.

community How true is the statement: dead follicles don't grow back?

112 upvotes 1 year ago

Hair follicles usually go dormant rather than die, and treatments like finasteride, minoxidil, and hormone therapy can sometimes reactivate them, though results vary. Complete regrowth is rare, especially in long-term bald areas, but some individuals see significant improvement with these treatments.

community Microneedling must reach the stem cells in the upper hair shaft

82 upvotes 4 years ago

Microneedling should target depths of 0.5mm to 1.5mm for hair loss, with weekly sessions at 1mm recommended. Combining microneedling with Minoxidil is common for improved results.

community Confused why people are calling PP405 a cure...it never claimed to be able to undo miniaturization or revert vellus back to terminal hairs. It seems to be more of a growth stimulant like minoxidil.

in Research/Science 55 upvotes 1 year ago

PP405 is not a cure for hair loss but may reactivate dormant hair follicles, similar to minoxidil. It is unlikely to help with miniaturized or vellus hairs and is still in trial phases, with availability expected around 2030.

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