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    GlossaryAndrogen Receptor Gene Polymorphism (AR Polymorphism)

    variations in the DNA sequence of the androgen receptor gene

    Androgen Receptor Gene Polymorphism refers to variations in the DNA sequence of the androgen receptor (AR) gene, which can affect how the body responds to androgens, such as testosterone. These genetic differences can influence a range of physiological traits and conditions, including hair growth patterns and susceptibility to conditions like androgenetic alopecia (male or female pattern baldness).

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      learn Pyrilutamide

      highly targeted anti-androgen that might have minimal systemic effects

      learn GT20029

      research compound made to degrade androgen receptors in scalp

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      community GT-20029 should be much more superior than finasteride

      in Research/Science  42 upvotes 6 months ago
      GT-20029 is discussed as a potential hair loss treatment, with concerns about its safety and systemic absorption compared to finasteride. Users express skepticism about its effectiveness and safety, noting that it may not surpass existing treatments like finasteride and minoxidil.

      community Creatine is the opposite of minoxidil !

      in Research/Science  322 upvotes 2 weeks ago
      Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

      community How to reduce scalp DHT as much as possible?

      in Finasteride/Dutasteride  16 upvotes 4 weeks ago
      The conversation discusses reducing scalp DHT to prevent hair loss, with a focus on using dutasteride, finasteride, and other treatments like RU58841 and minoxidil. It highlights the challenges of managing hair loss while on high testosterone levels, suggesting that dutasteride may be more effective than finasteride in such cases.

      community Maintaining hair until Breezula without Fin

      in Treatment  6 upvotes 5 years ago
      A 21-year-old male experienced side effects from topical finasteride and is seeking alternative treatments to maintain hair until Breezula is available. He is considering using minoxidil, Nizoral, micro-needling, and vitamin D supplementation, and may try CB or RU58841 if necessary.