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GlossaryAndrogen Receptor Gene Polymorphism (AR Polymorphism)

variations in the DNA sequence of the androgen receptor gene

Androgen Receptor Gene Polymorphism refers to variations in the DNA sequence of the androgen receptor (AR) gene, which can affect how the body responds to androgens, such as testosterone. These genetic differences can influence a range of physiological traits and conditions, including hair growth patterns and susceptibility to conditions like androgenetic alopecia (male or female pattern baldness).

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community Maintaining hair until Breezula without Fin

in Treatment 6 upvotes 4 years ago

A 21-year-old male experienced side effects from topical finasteride and is seeking alternative treatments to maintain hair until Breezula is available. He is considering using minoxidil, Nizoral, micro-needling, and vitamin D supplementation, and may try CB or RU58841 if necessary.

community Huberman tweet about finasteride

in Finasteride/Dutasteride 278 upvotes 10 months ago

The conversation is about the side effects of finasteride, including Post Finasteride Syndrome, with varied personal experiences and differing views on the credibility of information sources. Some participants also discuss using minoxidil as a hair loss treatment.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community Kintor Pharmaceutical Announces AR-PROTAC (GT20029) Approved for Acne and Androgenic Alopecia Clinical Trials in China

in Technology 14 upvotes 3 years ago

The conversation discusses the approval of Kintor Pharmaceutical's AR-PROTAC (GT20029) for clinical trials in China for acne and androgenic alopecia. One user expresses optimism about new treatments being developed and seeks clarification on how the new drug works, specifically if it temporarily degrades the AR protein to reduce DHT sensitivity in hair follicles.

community ghk-cu is potent 5-ar inhibitor?

in Product 8 upvotes 8 months ago

GHK-Cu is a potent inhibitor of the type 1 5-alpha reductase enzyme in hair follicles, which may reduce hair loss without the side effects associated with type 2 5-alpha reductase inhibitors. The user previously experienced side effects with 5-alpha reductase inhibitors and is considering GHK-Cu as an alternative.

community What blood markers to get tested before starting any 5-AR inhibitor?

in Treatment 4 upvotes 4 months ago

The conversation is about which blood markers to test before starting a 5-AR inhibitor for hair loss. The user mentions already testing Total T, Free T, SHBG, Estradiol, Haematocrit, Red blood cell count, and White cell count, and asks if DHT or additional markers are needed.

community Glycine supplementaion is said to strongly upregulate 5-alpha Reductase (5-ar) Activity

in Research/Science 15 upvotes 3 years ago

Glycine supplementation may increase 5-alpha reductase activity, potentially affecting hair loss. Users discuss its impact on hair fall and its role in the body.

community Kintor Pharma Announces Completion of Subject Enrollment and Dosing in Phase I Clinical Trial of AR-PROTAC(GT20029) in the US_Kintor Pharmaceutical Limited

in Research/Science 60 upvotes 1 year ago

Kintor Pharma finished enrolling and dosing participants in a Phase I trial for a hair loss treatment called AR-PROTAC (GT20029). The effectiveness of another drug, pyrilutamide (KX-826), for hair loss will be clearer after a Phase 2 trial expected to complete in January 2023.

community Pyrilutamide ,the molecule’s true nature

in Research 302 upvotes 1 month ago

Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

community Will hair regenerate if androgen receptors are nuked?

in Research/Science 10 upvotes 1 year ago

Treatments for hair loss, such as using AR receptor blockers and degraders, to see if follicles can regenerate in the long term. The conversation also discusses how hair transplants could be a potential solution.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 96 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community Androgen degraders for hair loss

in Research/Science 59 upvotes 2 weeks ago

The conversation discusses androgen receptor degraders for hair loss, highlighting their potential advantages over traditional AR blockers like RU58841 and pyrilutamide. Concerns about the safety and cost of these treatments are also mentioned.

community So... any chinese suppliers for real pyri?

in Research/Science 6 upvotes 2 months ago

The conversation discusses sourcing pyrilutamide from China for hair loss treatment, highlighting its potency compared to other AR antagonists like bicalutamide and RU58841. The user expresses interest in trying pyrilutamide despite mixed results in clinical trials.

community The closest thing to a cure before hair cloning or genetic via?

in Treatment 9 upvotes 1 year ago

The conversation discusses using finasteride or dutasteride to reduce DHT, CosmeRNA to target androgen receptors, and Minoxidil as a vasodilator for hair growth. The regimen aims to maintain hair by addressing DHT-AR ratio and continuous Minoxidil use.

community Can you beat this 104 year old man‘s hair count?

in Styling 748 upvotes 2 years ago

A 104 year old man's impressive head of hair and speculations about how he has been able to maintain it; treatments such as minoxidil, finasteride, RU58841, dutasteride, 5-AR blockers, and other supplements are discussed.

community Silicon Valley backed company aims to cure hair loss

in Technology 51 upvotes 2 years ago

A Silicon Valley-backed company aims to cure hair loss. Exciting advancements include mRNA therapies, gene editing, hair cloning, AR degraders, anti-androgens, cell-based rejuvenation, and AI-based drug discovery, with hopes for FDA approval of GT20029 within 10 years.

community Fluridil downregulates androgen receptor expression?

in Research/Science 1 upvotes 8 months ago

Fluridil may decrease the number of androgen receptors in hair follicles by up to 95%. This suggests a different action mechanism from other non-steroidal antiandrogens like RU58841, indicating they might be used together.

community How does Pyrilutamide compare to RU58841 when it comes to androgen receptor binding affinity?

in Research/Science 24 upvotes 2 years ago

The relative strength of Pyrilutamide compared to RU58841 in terms of androgen receptor binding affinity. It has been noted that Pyrilutamide is 4x stronger than RU58841, with a higher binding affinity than DHT itself.

community Does CosmeRNA target the root cause of MPB?

in Chat 1 year ago

. CumsOnYourFeet69 has been discussing a new treatment called CosmeRNA which claims to target the root cause of male pattern baldness, and is considering using it in conjunction with Minoxidil instead of Finasteride due to possible side effects. Replies have highlighted that the efficacy of this treatment is still unknown, but it could be used as an effective maintenance option if successful.

community Is Keto shampoo 2% even worth starting?

in Ketoconazole 45 upvotes 1 month ago

Ketoconazole shampoo is primarily for scalp health and reducing inflammation, not hair regrowth. Combining ketoconazole with finasteride can yield similar results to using minoxidil and finasteride together.

community Spironolactone or bicalutamide prescription

in Treatment 4 upvotes 11 months ago

The conversation is about someone seeking a doctor in the EU who prescribes spironolactone or bicalutamide for female pattern hair loss, as they are having difficulty finding treatment options beyond Minoxidil in Austria. They are asking for recommendations and are open to direct messages for assistance.

community 3 months progress!! Fin + Min + Derma roller + Nizoral Shampoo.

in Progress Pictures 568 upvotes 1 year ago

The post discusses a user's successful hair regrowth after 3 months using 1 mg oral finasteride, oral minoxidil, weekly 1.5mm derma rolling, and Nizoral shampoo every other day, with no side effects. The conversation includes various responses, questions about the user's ethnicity and previous scalp condition, and suggestions for topical treatments.

community Topical Pyrilutamide - Hormone Panel

in Treatment 2 upvotes 1 year ago

The user used 0.5 mL of 0.5 mg of Pyrilutamide for 60 days for hair loss, but didn't notice any hair growth. They shared their hormone panel results and are seeking advice on next steps.

community All Drugs in Clinical Trials in 2023

in Research/Science 71 upvotes 1 year ago

12 companies having drugs or therapies in clinical trials during 2023, with various molecules and phases of trial; the probability that some may fail; and progress being made in the field.

community Kintor’s GT20029 Phase 1 success

in Update 74 upvotes 1 year ago

Kintor's GT20029, a treatment for hair loss, has completed Phase 1 successfully, showing promise as an androgen receptor degrader that could potentially regrow hair. It is considered more effective than Pyrilutamide, with infrequent dosing and minimal systemic absorption.

community GT20029. Kintor Pharma’s Product

in Research/Science 13 upvotes 1 year ago

The conversation discusses GT20029, a compound by Kintor Pharma that degrades androgen receptors and is in trials, with potential as a hair loss cure. Another promising treatment mentioned is an antibody that blocks prolactin and has shown positive results in macaques.

community Would Fluridil and Alfatradiol work effectively in conjunction with each other?

in Treatment 9 upvotes 4 years ago

Whether using both Fluridil and Alfatradiol together could be more effective than either one alone as a hair loss treatment, given their different mechanisms of action.

community How to Keep Your Hair on Steroids

in Treatment 14 upvotes 2 weeks ago

To minimize hair loss while using steroids, use finasteride or dutasteride and apply topical anti-androgens like RU58841. Avoid high doses of hair-toxic steroids; prefer testosterone, nandrolone, and boldenone.

community Finasteride + Cialis together long term?

in Treatment 3 upvotes 1 month ago

The user has been on 1mg finasteride for a year, experiencing low libido and moderate erectile issues. They are considering using Cialis daily with finasteride long term to address these side effects.

community To everyone who cant use FIN and doesnt want to use RU

in Treatment 33 upvotes 1 month ago

A new hair loss treatment, KX-826, is being discussed as a stronger and safer alternative to RU58841 and finasteride. Opinions are mixed, with some users skeptical about its effectiveness and others considering it as part of their regimen.