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Sex Hormones and Antiandrogens Influence In Vitro Growth of Dermal Papilla Cells and Outer Root Sheath Keratinocytes of Human Hair Follicles

research Sex Hormones and Antiandrogens Influence In Vitro Growth of Dermal Papilla Cells and Outer Root Sheath Keratinocytes of Human Hair Follicles.

12 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that hair follicle cells' growth in vitro is influenced by the concentration of androgens and antiandrogens, with papilla cells and outer root sheath keratinocytes showing distinct sensitivity.

research Sex hormones and antiandrogens influence in vitro growth of dermal papilla cells and outer root sheath keratinocytes of human hair follicles

9 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that the in vitro growth of hair follicle cells, particularly papilla cells and outer root sheath keratinocytes, is influenced by different concentrations of androgens and antiandrogens.

research Effects of Prenatal Treatment with Antiandrogens on Luteinizing Hormone Secretion and Sex Steroid Concentrations in Adult Spotted Hyenas, Crocuta crocuta1

37 citations , November 2002 in “Biology of Reproduction”

This study found that prenatal antiandrogen treatment in female spotted hyenas significantly altered the LH response to GnRH, indicating partial masculinization of their anterior pituitary gland without affecting ovulatory function.

research Changes of sex hormone levels in male acne patients with normal serum testosterone and effect of antiandrogen therapy

January 2009 in “Academic Journal of Second Military Medical University”

In this study, adolescent male acne patients with normal serum testosterone showed improved outcomes with finasteride plus lifestyle intervention, significantly reducing DHT and free testosterone levels and improving SHBG levels, with minimal adverse effects.

research Effects of Flutamide, a pure antiandrogen, on endocrine parameters, in the adult female rat

8 citations , January 1987 in “Gynecological Endocrinology”

This study found that treatment with the pure antiandrogen Flutamide did not affect the estrous cycle or plasma levels of most hormones in female rats, supporting its potential use for treating hirsutism, acne, and alopecia in women.

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community Hormone Management Advice - Aromatase Inhibitors , SHBG Blockers

in Finasteride/Dutasteride 5 upvotes 1 year ago

The user plans to switch from minoxidil to finasteride or dutasteride for hair loss, while managing hormones with aromatase inhibitors and SHBG blockers. They seek advice on the best options for these treatments, considering past side effects and future therapies.

community Why are hormone blockers more socially acceptable than hair systems or balding?

in Chat 105 upvotes 5 months ago

Finasteride is more accepted than hair systems because it is less visible and maintains natural hair. Treatments like minoxidil and finasteride are commonly used for hair loss, but opinions on hair systems vary.

community For people with overly oily hair, does topical finasteride/dutasteride/antiandrogens (like RU or Pyrilutamide) reduce sebum overproduction?

in Finasteride/Dutasteride 6 upvotes 3 years ago

The conversation discusses whether topical finasteride, dutasteride, or antiandrogens like RU58841 can reduce sebum overproduction as an early indicator of their effectiveness in treating hair loss. It suggests that while hair growth may take months to observe, a decrease in oiliness could be a quicker sign of a product's action.

community Has anyone find a way to stop/limit ru58841 to go systematic ?

in Finasteride/Dutasteride 4 upvotes 1 year ago

RU58841 is a strong non-steroidal antiandrogen for hair loss but may cause cardiovascular issues in some users. Alternatives like Pyrilutamide and Breezula are suggested due to better safety profiles and lower systemic risks.

community (MTF 35) Results of 18 Months of HRT

775 upvotes 8 months ago

A transgender woman experienced significant hair regrowth after 18 months of hormone replacement therapy (HRT) with estrogen and bicalutamide. The discussion notes HRT's effectiveness for hair regrowth but warns against its use for cisgender men due to feminizing effects.

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Learn

7 / 801 results

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn Minoxidil

An essential vasodilator with some anti-androgenic effects

learn Azelaic Acid

acid used for antimicrobial, anti-inflammatory and anti-androgenic properties

learn Bicalutamide

a nonsteroidal anti-androgen, most commonly used orally for women

Can bicalutamide stop DHT from shrinking your hair follicles? Bicalutamide blocks androgens at the receptor rather than lowering DHT, and some dermatologists prescribe it off-label for women with pattern hair loss. The published evidence is retrospective case series and one small pilot study, with no randomized trial; it is a prescription drug that requires liver monitoring and is contraindicated in pregnancy.
Why are some women using bicalutamide to fight hormonal hair loss? Bicalutamide blocks androgens, helping women combat hormonal hair loss effectively.

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Pyrilutamide

Is pyrilutamide a safer alternative to oral antiandrogens like finasteride? Pyrilutamide may be a safer topical alternative to oral antiandrogens like finasteride.

learn Follistatin

How does follistatin compare to finasteride or dutasteride for treating androgenic alopecia? Finasteride and dutasteride are prescription drugs with large controlled trials showing they lower DHT and slow androgenic hair loss, at the cost of documented hormonal side effects; follistatin targets a different, regenerative pathway but has only one small phase 1 human trial behind it, so it is experimental with unknown safety rather than a comparable alternative.

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