November 2021 in “Circulation” SCAD can indicate ANA-negative lupus, especially in women with unusual symptoms.
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February 2023 in “International Journal of Rheumatic Diseases” TB can mimic SLE symptoms, so doctors should consider TB in such cases.
This article discusses a rare case of antinuclear antibody (ANA)-negative systemic lupus erythematosus (SLE) in a 16-year-old South Asian female, who presented with generalized lymphadenopathy, fever, alopecia, oral ulcers, purpuric rashes, and polyarthritis. Despite the absence of detectable ANA, the patient had strongly positive anti-double-stranded DNA antibodies and met four American College of Rheumatology classification criteria for SLE. The case highlights the diagnostic challenges of ANA-negative SLE, particularly in South Asia, and underscores the importance of comprehensive diagnostic criteria like the SLICC 2012. The patient responded well to corticosteroid and hydroxychloroquine therapy, emphasizing the need for early recognition and treatment in pediatric patients with multisystem involvement.
31 citations
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March 2018 in “Frontiers in Immunology” The document concludes that anti-dsDNA antibodies are not unique to SLE and their use as indicators is doubtful, highlighting the need for better understanding and classification of the disease.
63 citations
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December 2007 in “Lupus” SLE symptoms in Dubai are similar to those in other Arab and Western countries.