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Glossary Female Pattern Hair Loss

genetic and hormonal hair thinning on women's crown and frontal scalp

Female Pattern Hair Loss (FPHL), also known as female androgenetic alopecia, is a common form of hair loss in women characterized by a diffuse thinning of hair on the crown and frontal scalp while maintaining the frontal hairline. It is often linked to genetic and hormonal factors, particularly the influence of androgens, and can begin as early as the late teens or early twenties, progressively worsening with age.

Related Terms

Research

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research Female pattern hair loss may be triggered by low oestrogen to androgen ratio.

9 citations , March 2008 in “PubMed”

This study observed that women with female pattern hair loss had a significantly lower ratio of estradiol to free testosterone compared to healthy controls, suggesting a potential hormonal trigger for hair loss.

research Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee

49 citations , February 2019 in “The Journal of Clinical Endocrinology and Metabolism”

This review offers evidence-based recommendations for diagnosing and treating female pattern hair loss, emphasizing clinical assessment and starting treatment with minoxidil, while noting that measurement of certain hormones and vitamins is optional.

research Efficacy and Safety of Minoxidil 2% Solution in Combination With a Botanical Hair Solution in Women With Female Pattern Hair Loss/Androgenic Alopecia.

2 citations , April 2016 in “PubMed”

This study found that a 12-week regimen of 2% minoxidil combined with a botanical hair solution improved hair growth and patient satisfaction for female pattern hair loss, aiding treatment adherence.

research Evaluation of Susceptibility Genes/Loci Associated with Male Androgenetic Alopecia (MAGA) for Female-Pattern Hair Loss in a Chinese Han Population and a Brief Literature Review

1 citations , August 2021 in “Medical Science Monitor”

This study found no significant association between genetic loci linked to male androgenetic alopecia and female-pattern hair loss in a Chinese Han population, suggesting they are etiologically separate disorders.

research EXPRESS: Free androgen index and its relation with female pattern hair loss

May 2025 in “Journal of Investigative Medicine”

This study concluded that the Free Androgen Index (FAI) could serve as a reliable biomarker for hyperandrogenism in women with androgenetic alopecia, showing more predictive value than testosterone or SHBG alone.

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Community Join

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community Clascoterone might be the Finasteride for female pattern hair loss.

9 upvotes 2 months ago

Clascoterone, a topical anti-androgen, shows promise for treating female pattern hair loss without systemic side effects, offering a potential alternative to minoxidil. It could also benefit men who experience side effects from finasteride.

community I have female pattern hairloss at 18 and stuck between PRP and minoxidil

5 upvotes 3 weeks ago

An 18-year-old with female pattern hair loss is considering between PRP and minoxidil treatments. Concerns include lifelong use of minoxidil, potential harm to pets, and unwanted hair growth, while PRP is seen as costly with minimal gains; oral minoxidil is suggested as an alternative.

community I’m crashing out (female pattern hair loss)

40 upvotes 1 month ago

A woman experiencing female pattern hair loss has been using topical minoxidil and ketoconazole shampoo but is seeking further treatment options due to plateaued results. Suggestions include spironolactone, finasteride, dutasteride, and other treatments like PRP, while emphasizing the importance of consulting a dermatologist and conducting thorough medical evaluations.

community AGA/male pattern baldness and loss of hair in the past 6months

52 upvotes 8 months ago

A 25-year-old male experienced significant hair loss due to telogen effluvium and androgenetic alopecia. He began using finasteride, minoxidil, and vitamins, seeing some regrowth but remains worried about hair density.

community Female diffuse hair loss on spiro with irregular periods (photos) + genetic hair loss

in Female 16 upvotes 2 years ago

A 34-year-old woman is experiencing diffuse hair loss and irregular periods, possibly due to long-term spironolactone use. She is considering minoxidil and finasteride for treatment and seeking medical advice for androgenic alopecia and hormonal imbalances.

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Learn

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learn Hair Transplant

What causes male pattern baldness? Male pattern baldness is caused by genetic sensitivity to the hormone DHT.
Can women get hair transplants? Women can get hair transplants, and procedures are tailored to their specific hair loss patterns.

learn Cetirizine

popular antihistamine showing promise for hair loss as an anti-inflammatory and prostaglandin inhibitor

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small unblinded pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn Bicalutamide

a nonsteroidal anti-androgen, most commonly used orally for women

Can bicalutamide stop DHT from shrinking your hair follicles? Bicalutamide blocks androgens at the receptor rather than lowering DHT, and some dermatologists prescribe it off-label for women with pattern hair loss. The published evidence is retrospective case series and one small pilot study, with no randomized trial; it is a prescription drug that requires liver monitoring and is contraindicated in pregnancy.

learn Metformin

Does metformin help control DHT levels that trigger androgenic alopecia? Metformin has been shown to lower circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Spironolactone

powerful topical and oral anti-androgen used mostly by women

learn Estradiol

an estrogen promoting hair regrowth more commonly used in women

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Clinics

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Hair Systems
Wanda Patterson @ Affluent Hair SolutionsMarina del Rey, CA · US

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