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Glossary Androgen-Dependent

biological process influenced by male sex hormones

Androgen-dependent refers to biological processes or conditions that are influenced or regulated by androgens, which are male sex hormones like testosterone. For example, androgen-dependent hair loss, also known as androgenetic alopecia, occurs when hair follicles shrink due to the effects of these hormones, leading to thinning hair or baldness. This term is crucial in understanding conditions that are influenced by hormonal changes, particularly in the context of hair growth and loss.

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Research

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research Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factor(s) in Response to Testosterone Unlike Scalp Cells

51 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, researchers found that while both beard and scalp dermal papilla cells release similar autocrine growth factors, only beard cells increased production and response with testosterone, suggesting these factors enhance androgen-induced hair growth.

research Cultured dermal papilla cells from androgen-dependent human hair follicles (e.g. beard) contain more androgen receptors than those from non-balding areas of scalp

124 citations , April 1992 in “Journal of Endocrinology/Journal of endocrinology”

This study observed that cells from androgen-sensitive areas like the beard and scrotum showed higher androgen receptor levels compared to those from non-balding scalp areas, supporting the role of dermal papilla in follicle growth responses to androgens.

A Controlled Study of the Effects of RU58841, a Non-Steroidal Antiandrogen, on Human Hair Production by Balding Scalp Grafts Maintained on Testosterone-Conditioned Nude Mice

research A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice

10 citations , November 1997 in “British Journal of Dermatology”

This study found that the non-steroidal antiandrogen RU58841 increased hair growth rates and promoted hair cycle initiation in balding human scalp grafts on testosterone-conditioned nude mice, indicating a positive effect on hair growth.

research Dose-dependent and long term effects of RU58841 (androgen receptor blocker) on hair growth in the bald stumptailed Macaque.

1 citations , January 1997 in “Journal of Investigative Dermatology”

In this study using a macaque model, RU58841 at a 5% concentration significantly increased hair density, thickness, and length in the frontal bald scalp over six months.

research Alopecia areata incognito: an elusive disease

December 2023 in “International Journal of Dermatology”

This study reports that trichoscopy and histopathology can effectively diagnose alopecia areata incognito and differentiate it from telogen effluvium or androgenetic alopecia, aiding clinicians in better hair regrowth management.

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Community Join

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community A new study by Deng and colleagues set out to explore differences between balding and non balding scalps...

39 upvotes 4 years ago

Balding scalps have more androgen receptors, leading to increased TGF-beta, which causes blood vessel loss and hair follicle miniaturization. Blocking androgen signaling and TGF-beta may help prevent hair loss.

community Why are the results so varied depending on WHERE you’re balding??

in Chat 9 upvotes 1 month ago

Minoxidil and finasteride are more effective for diffuse thinning and crown balding because these areas have miniaturizing but still alive hairs that respond well to treatment. The hairline is less responsive to these medications due to its androgen sensitivity and often requires a transplant for restoration.

community Minoxidil is a 5ar inhibitor according to research

150 upvotes 11 months ago

Minoxidil may inhibit androgen receptors and affect hormonal pathways, potentially explaining its effectiveness in treating androgenetic alopecia (AGA). Users discuss its varying effectiveness on scalp versus facial hair and note fewer side effects with topical use compared to oral.

community Sugar and Hair loss connections

in Research/Science 41 upvotes 1 year ago

High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.

community Why some people experience problems on Finasteride/Dutasteride (my theory)

in Research/Science 18 upvotes 9 months ago

Some people have side effects from finasteride and dutasteride due to hormonal predisposition, especially if DHT dominant. Alternatives like RU58841, Pyrilutamide, and Breezula are suggested to target scalp androgen receptors without altering overall hormones.

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Learn

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learn Pyrilutamide

highly targeted anti-androgen that might have minimal systemic effects

learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

learn Overview

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Estradiol

Is applying Estradiol directly to the scalp effective for hormone-related hair thinning? Applying Estradiol directly to the scalp may help with hormone-related hair thinning.

learn Bicalutamide

What results can you expect from using bicalutamide on your scalp? There is no published human study of bicalutamide applied to the scalp for hair loss, no licensed topical product and no established dose, so no result can be predicted from it. The evidence that exists is for the oral tablet in women, which is a prescription drug requiring liver monitoring and contraindicated in pregnancy.

learn Bimatoprost

What do the latest studies say about bimatoprost for scalp hair growth? Bimatoprost is approved only for eyelashes; a 30-person pilot found it beat a topical steroid on patches of alopecia areata, but the two registered Allergan trials in male pattern hair loss were never published and never taken further, so scalp use stays off-label and experimental.

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Clinics

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Experts

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24
Trichologist
Kirsten J. Scalp
Greenville, SC, United States

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Kirsten J. Scalp