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Glossary AKT signaling pathway

regulates cell growth, survival, and metabolism

The AKT signaling pathway, also known as the Protein Kinase B (PKB) pathway, is a crucial cell signaling system that regulates various cellular processes, including growth, survival, and metabolism. It is activated by growth factors and other extracellular signals, leading to the phosphorylation and activation of AKT, which then influences numerous downstream targets to promote cell proliferation and inhibit apoptosis (cell death). This pathway is significant in many physiological contexts and is often implicated in cancer and other diseases due to its role in cell survival and growth.

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research Pannexin 3 regulates skin development via Epiprofin

13 citations , January 2021 in “Scientific Reports”

This study found that Pannexin 3 plays a crucial role in skin development by regulating the transcription factor Epiprofin, affecting keratinocyte differentiation and hair follicle regeneration in mice.

Therapeutic Potential of Nerve Growth Factor-Modified Hair Follicle Stem Cells Transplantation in a Rat Model of Alzheimer's Disease

research Therapeutic Potential of Nerve Growth Factor-Modified Hair Follicle Stem Cells Transplantation in a Rat Model of Alzheimer’s Disease

February 2026 in “Journal of Integrative Neuroscience”

In this study, transplantation of hair follicle stem cells and nerve growth factor-modified stem cells significantly reduced amyloid deposition and tau hyperphosphorylation in an Alzheimer's disease rat model, suggesting potential as a treatment option.

research NF-κB in biology and targeted therapy: new insights and translational implications

1 citations , March 2024 in “Signal transduction and targeted therapy”

In this review, researchers explored the multifaceted role of NF-κB signaling in various biological processes and diseases, including its interactions with other pathways, and discussed possible therapeutic approaches targeting this pathway for treating conditions like cancer, autoimmune disorders, and COVID-19.

Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Hair Regrowth in C57BL/6 Mice Through Upregulation of the RAS/ERK Signaling Pathway

research Exosomes derived from Umbilical cord mesenchymal stem cell promote hair regrowth in C57BL6 mice through upregulation of the RAS/ERK signaling pathway

November 2024 in “Journal of Translational Internal Medicine”

This study found that umbilical cord mesenchymal stem cell-derived exosomes improved hair growth in mice with androgenetic alopecia by promoting hair follicle stem cell stemness through the RAS/ERK pathway, suggesting a potential new treatment strategy for this condition.

research Regulation of pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway (Review)

18 citations , July 2021 in “Molecular Medicine Reports”

This review summarizes existing knowledge of how the WNT signaling pathway affects mesenchymal stem cells under various conditions, highlighting challenges and mechanisms for clinical applications.

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