Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice

    Nadine Brandes, Slavica Hristomanova Mitkovska, Dominik Simon Botermann … Anja Uhmann
    Studysummary This study suggests that biallelic loss of the Hedgehog signaling repressor Patched alone in Keratin 5+ epidermal cells is insufficient to drive basal cell carcinoma development unless exogenous stimuli trigger accumulation of BCC precursor cells.
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    Research cited in this study 5

    1. Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis Frontiers in genetics · 2019
    2. DMBA/TPA Treatment Is Necessary for Basal Cell Carcinoma Formation from Patched Deficient Epidermal Cells in Ptch Flox/Flox CD4Cre +/- Mice Journal of Investigative Dermatology · 2014
    3. Basal Cell Carcinomas in Mice Arise from Hair Follicle Stem Cells and Multiple Epithelial Progenitor Populations Journal of Clinical Investigation · 2011
    4. Patched1 Functions as a Gatekeeper by Promoting Cell Cycle Progression Cancer Research · 2006
    5. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003