Novel Effect of Sildenafil on Hair Growth

October 2018 in “ Biochemical and Biophysical Research Communications ”

Hye In Choi, Bomi Kang, Jaehee Jang, Sungjoo Hwang, Oh Sang Kwon

sildenafil hair growth alopecia human dermal papilla cells hDPCs VEGF PDGF ERK pathway perifollicular vessel formation telogen anagen Viagra hair loss vascular endothelial growth factor platelet-derived growth factor resting phase growth phase

Studysummary In this study, sildenafil was found to enhance human dermal papilla cell proliferation and promote hair growth in mice, suggesting potential use in alopecia treatment.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

12 / 12 results

research The Effect of Cilostazol, a Phosphodiesterase 3 (PDE3) Inhibitor, on Human Hair Growth with Dual Promoting Mechanisms

21 citations , April 2018 in “Journal of Dermatological Science”

This study found that topical cilostazol promotes hair growth, enhances hair follicle activities, and may serve as a potential treatment for alopecia.

research A Role of Placental Growth Factor in Hair Growth

31 citations , February 2014 in “Journal of dermatological science”

This study found that placental growth factor (PlGF) enhanced hair shaft elongation and accelerated hair follicle growth, suggesting its potential as a therapeutic target for alopecia.

research VEGF Induces Proliferation of Human Hair Follicle Dermal Papilla Cells Through VEGFR-2-Mediated Activation of ERK

120 citations , May 2012 in “Experimental Cell Research”

This study found that VEGF stimulates the proliferation of human hair follicle dermal papilla cells via the VEGFR-2/ERK pathway, without involving p38, JNK, or AKT signaling.

research Review of Hair Follicle Dermal Cells

321 citations , December 2009 in “Journal of Dermatological Science”

This review discusses the role of dermal cells in hair follicle regeneration and morphogenesis and highlights their potential therapeutic implications, but it reports no new empirical findings.

research Determination of the Sildenafil Effect on Alopecia Areata in Childhood: An Open-Pilot Comparison Study

12 citations , January 2006 in “Journal of Dermatological Treatment”

This open-pilot study found that topical 1% sildenafil did not show significant hair growth in children with alopecia areata, as outcomes seemed due to spontaneous disease regression.

research A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss

219 citations , March 2004 in “Journal of The American Academy of Dermatology”

In this 48-week trial, 5% topical minoxidil was more effective than both 2% minoxidil and placebo in promoting hair growth in women with female pattern hair loss, with notable improvements in nonvellus hair count and hair growth assessments.

research Topical Minoxidil Counteracts Stress-Induced Hair Growth Inhibition in Mice

30 citations , September 2003 in “Experimental Dermatology”

In this study on a murine model, researchers observed that a 5% minoxidil solution reduced stress-induced changes in hair growth, suggesting its potential for managing stress-related hair loss in humans.

research Molecular Mechanisms Regulating Hair Follicle Development

854 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review summarizes recent advances in understanding the molecular mechanisms of hair follicle formation and discusses potential future clinical applications for treating hair loss and skin tumors, but it reports no new clinical results.

research Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog

231 citations , October 1999 in “Journal of Clinical Investigation”

This study found that administering an adenovirus vector to increase Sonic hedgehog gene expression in mouse skin accelerated the transition of hair follicles into the growth phase, promoting hair growth.

research Topical Minoxidil for Hair Regrowth

80 citations , September 1984 in “Journal of The American Academy of Dermatology”

In this study, 5% topical minoxidil was observed to promote hair regrowth in some patients with androgenic alopecia, while no regrowth was noted in patients with alopecia areata.

Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

137 citations , May 1984 in “Journal of Investigative Dermatology”

Minoxidil increases blood flow in balding scalps, possibly reversing hair loss.

research Alopecia Areata Treated With Topical Minoxidil

78 citations , April 1984 in “Archives of Dermatology”

This study found that 1% minoxidil topical solution led to terminal hair regrowth in some patients with alopecia areata, though it was only cosmetically acceptable in less than half of those cases.