Environmental Modulation of JAK3-Mediated Immune Dysregulation in Alopecia Areata
November 2025
in “
Scholarly Commons (Embry–Riddle Aeronautical University)
”
New to Alopecia Areata? There is a guide in the encyclopedia. Read the guide → alopecia areata autoimmune disorder hair loss T-cell hair follicles Janus kinase 3 JAK3 urban air pollutants fine particulate matter diesel exhaust ozone oxidative stress epigenetic changes JAK3–STAT signaling immune cells heavy metals endocrine disruptors nutritional status gut microbiome cytokine balance autoimmune activation biomarkers AA immune system pollutants air pollution gut health immune response
Studysummary This review discusses how urban air pollutants may influence the regulation of JAK3 signaling in alopecia areata and reports no new experimental results; the authors integrate existing data to map potential pathways and biomarkers.
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