Promising Improvement in Infected Wound Healing in Type 2 Diabetic Rats by Combined Effects of Conditioned Medium of Human Adipose-Derived Stem Cells Plus Photobiomodulation

November 2023 in “ Laboratory Animal Research ”

Kaysan Sohrabi, Houssein Ahmadi, Abdollah Amini, Behnaz Ahrabi, Atarodalsadat Mostafavinia, Hamidreza Omidi, Mansooreh Mirzaei, Fatemeh Fadaei Fathabady, Mohammadjavad Fridoni, Maryam Rahmannia, Sufan Chien, Mohammad Bayat

human adipose-derived stem cells conditioned medium photobiomodulation wound healing fibroblast blood vessel formation inflammation h-ASC-COM PBM

TLDR Combining stem cell medium and light therapy improves wound healing in diabetic rats.

The study investigated the effects of human adipose-derived stem cell conditioned medium (h-ASC-COM) and photobiomodulation (PBM) on wound healing in type 2 diabetic rats with infected wounds. The combination of h-ASC-COM and PBM significantly improved wound healing by reducing inflammation and microbial presence, and enhancing wound strength, closure rate, fibroblast count, and blood vessel formation. While both PBM alone and the combination treatment were more effective than h-ASC-COM alone, the combined treatment was superior to PBM alone.

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