Tissue Retinol-Binding Protein 4 Expression and Its Genetic Variants (rs3758539) in Patients With Severe and Treatment-Refractory Alopecia Areata: Association With Response to Baricitinib

    January 2026 in “ Dermatologic Therapy ”
    Eisa M. Hegazy, Mohammed H. Hassan, Moustafa A. El Taieb … Soheir Abdel‐Hamid
    Studysummary This study found that elevated tissue RBP4 levels correlate with disease severity in alopecia areata and decrease after effective baricitinib treatment, while the rs3758539 polymorphism is linked to disease susceptibility but not to treatment response.
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    Research cited in this study 13

    1. Baricitinib-Loaded EVs Promote Alopecia Areata Mouse Hair Regrowth by Reducing JAK-STAT-Mediated Inflammation and Promoting Hair Follicle Regeneration Drug Discoveries & Therapeutics · 2024
    2. Real-Life Effectiveness and Tolerance of Baricitinib for the Treatment of Severe Alopecia Areata with 1-Year Follow-Up Data Dermatology and Therapy · 2023
    3. Expecting Scalp Hair Regrowth During Severe Alopecia Areata Treatment with Baricitinib: Insights from Patient Trajectories in Phase III Trials British Journal of Dermatology · 2023
    4. Baricitinib for the Treatment of Alopecia Areata Drugs · 2023
    5. Efficacy and Safety of Baricitinib in Patients with Severe Alopecia Areata Over 52 Weeks in Phase III Trials American Journal of Clinical Dermatology · 2023
    6. Efficacy and Safety of Baricitinib in Patients With Refractory Alopecia Areata Dermatologic Therapy · 2022
    7. An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
    8. Serum Level of Retinol-Binding Protein 4 in Alopecia Areata: Relation with Recurrence and Severity Menoufia Medical Journal /Menoufia Medical Journal · 2022
    9. Adult Skin Acute Stress Responses to Short-Term Environmental and Internal Aggression from Exposome Factors Journal of the European Academy of Dermatology and Venereology · 2021
    10. Alopecia Areata: A Review on Diagnosis, Immunological Etiopathogenesis, and Treatment Options Clinical and Experimental Medicine · 2021
    11. Assessment of Retinol-Binding Protein 4 in Patients with Alopecia Areata and Androgenetic Alopecia Journal of the Egyptian Women's Dermatologic Society (Print) · 2016
    12. Increased Retinol-Binding Protein 4 and Anti-RBP4 Antibody in Alopecia Areata British Journal of Dermatology · 2011
    13. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010