Serum Level of Retinol-Binding Protein 4 in Alopecia Areata: Relation with Recurrence and Severity

January 2022 in “ Menoufia Medical Journal /Menoufia Medical Journal ”

OlaAbd El-Raheem Ahmed ElShaer, MagdaM Hagag, SherinS El-Naidany

retinol-binding protein 4 alopecia areata RBP4 alopecia areata tool score AA

Studysummary This study found that alopecia areata was associated with increased serum levels of retinol-binding protein-4 compared to controls, but no correlation with disease severity was observed.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on mmj.eg.net →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

research Cellular Retinol-Binding Protein-1 Expression Increases with Clinical Severity of Alopecia Areata

2 citations , December 2018 in “Journal of cosmetic dermatology”

This study observed a significant increase in cellular retinol-binding protein-1 expression in lesional skin of patients with alopecia areata compared to healthy controls, suggesting its potential role in the disease's pathogenesis.

research Assessment of Retinol-Binding Protein 4 in Patients with Alopecia Areata and Androgenetic Alopecia

September 2016 in “Journal of the Egyptian Women's Dermatologic Society (Print)”

This article explores the interactions between retinoids and the immune system but reports no new clinical results related to their role in hair cycle control.

research Drug Discovery for Alopecia: Gone Today, Hair Tomorrow

70 citations , February 2015 in “Expert Opinion on Drug Discovery”

This review discusses current knowledge on the biological mechanisms of different types of alopecia but reports no new clinical findings; the authors highlight future research directions, especially regarding epidermal stem cells and immune pathways.

research Endogenous Retinoids in the Pathogenesis of Alopecia Areata

54 citations , September 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that vitamin A influences the immune response and hair cycle, affecting the progression of alopecia areata in mouse models.

research Endogenous Retinoids in the Hair Follicle and Sebaceous Gland

50 citations , September 2011 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids”

This review examines the role of retinoic acid synthesis in hair follicles and sebaceous glands, focusing on its localization and function during normal and disease states, but reports no new results.

research Increased Retinol-Binding Protein 4 and Anti-RBP4 Antibody in Alopecia Areata

6 citations , June 2011 in “British Journal of Dermatology”

This study found that individuals with alopecia areata had significantly higher serum levels of retinol-binding protein 4 and increased IgG immunoreactivity against it, suggesting a role in the disease's pathogenesis.

research Etiopathogenesis of Alopecia Areata: Why Do Our Patients Get It?

53 citations , May 2011 in “Dermatologic therapy”

This article discusses the pathogenesis and possible biological mechanisms of alopecia areata but reports no new clinical results.

research Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

91 citations , November 2008 in “Journal of biological chemistry/The Journal of biological chemistry”

This study found that DGAT1 functions as a key enzyme in murine skin to regulate retinoic acid levels and prevent retinoid toxicity, impacting hair cycle and sensitivity to retinol.

research Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle

48 citations , March 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study observed that retinoic acid biosynthesis and signaling in hair follicles have a spatial and temporal regulation linked to distinct stages of the hair cycle in mice.

research Alopecia Areata Update

49 citations , April 2000 in “Journal of The American Academy of Dermatology”

This article discusses the etiology, clinical features, diagnosis, histopathology, and treatment of alopecia areata but reports no new clinical findings; it emphasizes the palliative nature of current treatments.