Serum Level of Retinol-Binding Protein 4 in Alopecia Areata: Relation with Recurrence and Severity

January 2022 in “ Menoufia Medical Journal /Menoufia Medical Journal ”

OlaAbd El-Raheem Ahmed ElShaer, MagdaM Hagag, SherinS El-Naidany

retinol-binding protein 4 alopecia areata RBP4 alopecia areata tool score AA

TLDR Higher levels of retinol-binding protein 4 are found in people with alopecia areata, but these levels don't relate to how severe the condition is.

The study investigated the serum levels of retinol-binding protein 4 (RBP4) in 52 patients with alopecia areata (AA), including 26 experiencing their first episode and 26 with recurrent AA, compared to 26 control patients. The results showed that RBP4 levels were significantly higher in AA patients than in controls (P < 0.001). However, there was no significant correlation between serum RBP4 levels and the severity of AA as measured by the alopecia areata tool score. The findings suggest that RBP4 may play a role in the pathogenesis of AA.

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Serum Level of Retinol-Binding Protein 4 in Alopecia Areata: Relation with Recurrence and Severity

Research cited in this study

research Cellular Retinol-Binding Protein-1 Expression Increases with Clinical Severity of Alopecia Areata

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research Drug Discovery for Alopecia: Gone Today, Hair Tomorrow

research Endogenous Retinoids in the Pathogenesis of Alopecia Areata

research Endogenous Retinoids in the Hair Follicle and Sebaceous Gland

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research Etiopathogenesis of Alopecia Areata: Why Do Our Patients Get It?

research Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

research Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle

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