Netherton Syndrome Subtypes Share IL-17/IL-36 Signature With Distinct IFN-α and Allergic Responses

    September 2021 in “ Journal of Allergy and Clinical Immunology ”
    Claire Barbieux, Mathilde Bonnet des Claustres, Matthias Fahrner … Alain Hovnanian
    Studysummary This study found IL-17/IL-36 signaling to be predominant in both endotypes of Netherton syndrome, with distinct molecular profiles between NS-ILC and NS-SE lesions, offering potential therapeutic targets.
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    Research cited in this study 4

    1. Emerging Topical and Systemic JAK Inhibitors in Dermatology Frontiers in Immunology · 2019
    2. Targeting the Janus Kinase Family in Autoimmune Skin Diseases Frontiers in Immunology · 2019
    3. Spink5-Deficient Mice Mimic Netherton Syndrome Through Degradation of Desmoglein 1 by Epidermal Protease Hyperactivity Nature Genetics · 2004
    4. Neutrophil Gelatinase-Associated Lipocalin Is a Marker for Dysregulated Keratinocyte Differentiation in Human Skin Experimental dermatology · 2002