Planar Cell Polarity Effector Gene Intu Regulates Cell Fate-Specific Differentiation of Keratinocytes Through the Primary Cilia

August 2012 in “ Cell death and differentiation ”

Dongfang Dai, L Li, Aaron J. Huebner, Hui-Qing Zeng, Elizabeth Guevara, David J. Claypool, Aimin Liu, J Chen

planar cell polarity PCP Intu gene hair follicle formation keratinocytes primary cilia hair follicle morphogenesis hedgehog signaling pathway epidermal stratification differentiation programs barrier function Intu hair follicles skin cells cilia hedgehog pathway skin layers skin differentiation skin barrier

Studysummary This study found that disrupting the inturned gene in developing mouse epidermis halted hair follicle formation due to impaired keratinocyte differentiation, highlighting primary cilia's role in tissue-specific planar cell polarity signaling.

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Planar Cell Polarity Effector Gene Intu Regulates Cell Fate-Specific Differentiation of Keratinocytes Through the Primary Cilia

Research cited in this study

research Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells

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