Upadacitinib Is Effective in Treating Psoriasis Combined with Lichen Planus: A Case Report

April 2026 in “ Frontiers in Medicine ”

Xingmo Li, Jinxu Qi, Liping Shi, Lijuan Liu, Xiaoyu Xie, Guoqiang Zhang, Qing Zhu

Upadacitinib psoriasis lichen planus acitretin mometasone Rinvoq Tazorac Elocon

Studysummary In this case report, a female patient with both psoriasis and lichen planus initially responded to acitretin and topical mometasone but experienced a relapse after stopping the treatment. The authors reported marked improvement within 3 months after switching to upadacitinib, aiming to guide clinical decision-making.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This case report discusses a female patient with coexisting psoriasis and lichen planus, conditions that are challenging to manage when they occur together. Initially treated with acitretin and topical mometasone, the patient discontinued these treatments due to safety concerns, leading to a relapse. The introduction of Upadacitinib resulted in significant improvement within 3 months. The report aims to enhance clinical decision-making by exploring the interaction between these diseases and the rationale for using Upadacitinib.

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