Janus Kinase Inhibitors in Dermatology: A Review
January 2023
in “
Portuguese Journal of Dermatology and Venereology
”
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Studysummary This review covers the use of JAK inhibitors in treating various dermatological conditions, emphasizing their potential while noting ongoing safety concerns with oral treatments; no new clinical results are provided. Our plain-language summary of this paper — not a Tressless recommendation.
Janus Kinase (JAK) inhibitors were found to be effective in treating various immune-related dermatological conditions, including atopic dermatitis, alopecia areata, psoriasis, and vitiligo, by blocking cytokine functions and gene transcription related to inflammation and immunity. While oral administration of JAK inhibitors was common, concerns about side effects led to the exploration of topical formulations, which appeared to be safe, well-tolerated, and a promising alternative.
