TLDR Baricitinib significantly improved hair regrowth and quality of life in severe alopecia areata patients.
This 52-week study assessed the efficacy and safety of baricitinib in 23 patients with moderate to severe alopecia areata (AA), showing significant hair regrowth with a decrease in the Severity of Alopecia Tool (SALT) score from 83.66 to 42.41. Patient-reported outcomes indicated improvements in quality of life and psychological well-being, with reductions in Skindex-16 and Hospital Anxiety and Depression Scale (HADS) scores. Trichoscopic assessments revealed a decrease in black and yellow dots and an increase in vellus hairs. Adverse effects were noted in 18.75% of patients, including genital candidiasis and menstrual irregularities. Despite these side effects, baricitinib was effective and had a favorable safety profile, supporting its use as a treatment for AA, though larger studies are needed for confirmation.
4 citations
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January 2024 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” Baricitinib and ritlecitinib are recommended for severe alopecia areata, with other treatments available off-label.
290 citations
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August 2021 in “Clinical Reviews in Allergy & Immunology” JAK inhibitors show promise for treating alopecia areata, but more research is needed.
17 citations
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January 2019 in “Journal of cutaneous medicine and surgery” JAK inhibitors show promise for treating hair loss in alopecia areata but need more clinical trials to confirm safety and effectiveness.
45 citations
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January 2013 in “Dermatology Research and Practice” Alopecia areata significantly worsens quality of life, suggesting a need for mental health support.
36 citations
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May 2011 in “Dermatologic therapy” No treatments fully cure or prevent alopecia areata; some help but have side effects or need more research.
July 2023 in “Research Square (Research Square)” Certain gut bacteria may protect against alopecia areata, while others may increase the risk.
4 citations
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October 2022 in “Genes” Our microbiome may affect the development of the hair loss condition Alopecia Areata, but more research is needed to understand this relationship.
November 2023 in “Research Portal Denmark” Baricitinib shows promise for severe alopecia areata but isn't a cure and has side effects.
Baricitinib is a new, effective treatment for advanced alopecia areata but is costly and has risks.
2 citations
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June 2023 in “Indian journal of dermatology, venereology, and leprology” Janus kinase inhibitors can regrow hair in alopecia areata but may cause side effects and hair loss may return if treatment stops.
57 citations
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August 2023 in “American Journal of Clinical Dermatology” JAK inhibitors and platelet-rich plasma show promise for treating alopecia areata.
