TLDR Baricitinib effectively reduces hair loss in severe alopecia areata with mild side effects.
The study assessed the effectiveness and safety of baricitinib in treating severe alopecia areata over 24 weeks in 118 Italian patients. Results showed significant hair regrowth, with 70% achieving a 50% improvement in the SALT score. The mean SALT score decreased from 96.6 to 48, with 42.3% achieving SALT 30, 31.3% achieving SALT 20, and 20.3% achieving SALT 10. Mild adverse events were reported in 12.7% of patients, with no drop-outs. The study supports baricitinib as a promising treatment for severe alopecia areata, especially in early stages, and recommends trichoscopy for early response detection.
September 2023 in “British Journal of Dermatology” Hair regrowth from severe alopecia areata treatment with baricitinib can vary, with faster results in those with shorter hair loss duration.
3 citations,
June 2023 in “Journal of dermatological treatment” Regrowing scalp hair improves quality of life and reduces anxiety and depression in severe alopecia areata patients.
6 citations,
May 2023 in “Drugs” Baricitinib helps regrow hair in adults with severe alopecia better than a placebo and is approved for treatment, but long-term effects are still unknown.
2 citations,
April 2023 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” JAK-inhibitors for alopecia areata are generally safe with mostly mild side effects and a low rate of treatment withdrawal.
148 citations,
May 2022 in “The New England Journal of Medicine” Baricitinib was effective in treating alopecia areata in two major trials.
47 citations,
January 2021 in “Journal of the European Academy of Dermatology and Venereology” The document concludes that understanding and treating hair loss requires recognizing its various types and using appropriate diagnostic tools and treatments.
37 citations,
December 2019 in “Giornale italiano di dermatologia e venereologia” The Italian guidelines offer advice for diagnosing and treating alopecia areata based on expert opinion and limited clinical trial evidence.
148 citations,
March 2019 in “Journal of autoimmunity” Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.
4 citations,
November 2018 in “JAAD case reports” Alopecia areata can sometimes appear as a straight line of hair loss instead of round patches.
May 2018 in “Journal of cosmetology & trichology” Combining platelet-rich plasma therapy with prostaglandin-F eye drops can significantly regrow hair in alopecia universalis.
