The Well-Forgotten Old: Platelet-Rich Plasma in Modern Anti-Aging Therapy

October 2024 in “ Cells ”

Anna V. Gorodilova, Chulpan B. Kharisova, Maria N. Osinnikova, Kristina V. Kitaeva, Ivan Y. Filin, Yuriy P. Mayasin, Valeriya V. Solovyeva, Albert A. Rizvanov

platelet-rich plasma growth factors tissue regeneration inflammation relief regenerative medicine esthetic medicine tissue repair PRP

TLDR PRP therapy shows promise for anti-aging but lacks consistent evidence and standardization.

Platelet-rich plasma (PRP) therapy is gaining popularity in personalized medicine due to its ability to release growth factors and other molecules that aid in tissue regeneration and inflammation relief. It shows potential in regenerative medicine and gerontology, being used in both esthetic medicine and to stimulate tissue repair. However, the clinical efficacy of PRP is debated due to inconsistent study results, lack of standardization in sample preparation, and insufficient objective data. This review explores the current clinical efficacy of PRP and its role in treating age-related diseases.

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Research cited in this study

9 / 9 results

research RETRACTED: The investigation and comparison of the efficacy and safety of stromal vascular fraction (SVF), platelet rich plasma (PRP), and 1064‐nm Q‐switched Nd:YAG laser in reducing nanofat treated infraorbital dark circles and wrinkles: A controlled blinded randomized clinical trial

7 citations , June 2024 in “Skin Research and Technology”

Evaluation of the Effects of Adding an Adipose Tissue-Derived Stromal Vascular Fraction to Platelet-Rich Plasma Injection in the Treatment of Androgenetic Alopecia: A Randomized Clinical Trial

research Evaluation of the Effects of Adding an Adipose Tissue-Derived Stromal Vascular Fraction to Platelet-Rich Plasma Injection in the Treatment of Androgenetic Alopecia: A Randomized Clinical Trial

April 2024 in “Skin research and technology”

Adding stromal vascular fraction to platelet-rich plasma injections did not significantly improve hair growth in androgenetic alopecia treatment.

research A Comprehensive Review on Platelet-Rich Plasma Activation: A Key Player in Accelerating Skin Wound Healing

2 citations , November 2023 in “Curēus”

Platelet-rich plasma (PRP) speeds up skin wound healing and has potential in medical and cosmetic uses.

Injections of Platelet-Rich Plasma Prepared by Automatic Blood Cell Separator Combined With Topical 5% Minoxidil in the Treatment of Male Androgenetic Alopecia

research Injections of Platelet-Rich Plasma Prepared by Automatic Blood Cell Separator Combined With Topical 5% Minoxidil in the Treatment of Male Androgenetic Alopecia

June 2023 in “Skin Research and Technology”

Using platelet-rich plasma injections and 5% minoxidil topically can safely and effectively treat mild-to-moderate male pattern baldness.

research Platelet-Rich Plasma for the Treatment of Erectile Dysfunction: A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

20 citations , April 2023 in “The Journal of Urology”

PRP is safe but not more effective than a placebo for treating mild to moderate erectile dysfunction.

research Efficacy of Autologous Platelet-Rich Plasma Therapy Versus Topical Minoxidil in Men With Moderate Androgenetic Alopecia: A Randomized Open-Label Trial

February 2023 in “Journal of Dermatological Treatment”

Minoxidil and PRP both help with hair growth, but Minoxidil has higher satisfaction and fewer side effects.

research Autologous Platelet-Rich Plasma Efficacy in Regenerative Medicine: Product and Quality Control

39 citations , January 2021 in “BioMed Research International”

PRP treatments need standardization for consistent results.

research Genetics and Other Factors in the Etiology of Female Pattern Hair Loss

43 citations , April 2017 in “Experimental Dermatology”

Female pattern hair loss has unclear causes, possibly involving genetics, hormones, and environment, and needs better treatments.

Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

research Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

136 citations , February 2017 in “International Journal of Molecular Sciences”

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

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The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review

research Convergent Regenerative Strategies in PM&R for Musculoskeletal and Hair Restoration: Integration of PRP, Exosomes, and Physical Modalities

January 2026 in “Archives of Internal Medicine Research”

PRP, exosomes, and physical therapies show promise for hair and tissue repair, but need more research for optimization.