The sheep KAP8-2 gene, a new KAP8 family member that is absent in humans

The study identified a new keratin-associated protein gene, KAP8-2, in sheep, which was absent in humans. This gene, located on sheep chromosome 1, exhibited two sequence variants and was rich in glycine and tyrosine but low in cysteine, with a unique high content of acidic amino acids. The research, involving 208 New Zealand Romney-cross sheep, suggested that KAP8-2 might play a role in the unique properties of sheep wool compared to human hair. The findings provided insights into genetic differences between species and contributed to the understanding of hair and wool fiber formation.