The Process of Cornification Evolved From the Initial Keratinization in the Epidermis and Epidermal Derivatives of Vertebrates: A New Synthesis and the Case of Sauropsids

January 2016 in “ International review of cell and molecular biology ”

Lorenzo Alibardi

cornification keratinization intermediate filament keratins keratin-associated proteins corneous proteins alpha-keratinization beta-keratinization epidermal keratinocytes terminal differentiation

TLDR Cornification evolved from keratinization in vertebrates, with differences between mammals and sauropsids.

The review discussed the evolution of cornification from initial keratinization in vertebrates, highlighting the role of intermediate filament (IF) keratins and their interaction with other proteins, such as keratin-associated proteins (KAPs) and corneous proteins. It emphasized that while alpha-keratinization was prevalent in mammals, beta-keratinization was specific to sauropsids, including reptiles and birds. The study suggested that the process of terminal differentiation in epidermal keratinocytes across vertebrates was a result of these interactions. Future research was recommended to explore the genes and proteins associated with keratin in fish and amphibians to further unify the concept of cornification in vertebrates.

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Research cited in this study

22 / 22 results

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The Process of Cornification Evolved From the Initial Keratinization in the Epidermis and Epidermal Derivatives of Vertebrates: A New Synthesis and the Case of Sauropsids

Research cited in this study

research Trichohyalin-Like Proteins Have Evolutionarily Conserved Roles in the Morphogenesis of Skin Appendages

research Cell Death by Cornification

research Cornification in Reptilian Epidermis Occurs Through the Deposition of Keratin-Associated Beta-Proteins (Beta-Keratins) Onto a Scaffold of Intermediate Filament Keratins

research Perspectives on Hair Evolution Based on Comparative Studies on Vertebrate Cornification

research Ultrastructural Localization of Hair Keratin Homologs in the Claw of the Lizard Anolis Carolinensis

research A Review of Keratin-Based Biomaterials for Biomedical Applications

research Evolution of Hard Proteins in the Sauropsid Integument in Relation to the Cornification of Skin Derivatives in Amniotes

research Identification of Reptilian Genes Encoding Hair Keratin-Like Proteins Suggests a New Scenario for the Evolutionary Origin of Hair

research Molecular Evolution of the Keratin Associated Protein Gene Family in Mammals: Role in the Evolution of Mammalian Hair

research Keratinization of Sheath and Calamus Cells in Developing and Regenerating Feathers

research Biology of the Wool Follicle: An Excursion into a Unique Tissue Interaction System Waiting to Be Rediscovered

research Human Hair Keratin‐Associated Proteins (KAPs)

research Structural and Immunocytochemical Characterization of Keratinization in Vertebrate Epidermis and Epidermal Derivatives

research Terrestrial vertebrates have two keratin gene clusters; striking differences in teleost fish

research Keratins of the Human Hair Follicle

research Comparative aspects of the inner root sheath in adult and developing hairs of mammals in relation to the evolution of hairs

research Expression of hair keratins in the adult nail unit: an immunohistochemical analysis of the onychogenesis in the proximal nail fold, matrix and nail bed

research Hair follicle differentiation and regulation.

research Structural changes in trichocyte keratin intermediate filaments during keratinization

research Epithelial Barrier Function: Assembly and Structural Features of the Cornified Cell Envelope

research ‘Hard’ and ‘soft’ principles defining the structure, function and regulation of keratin intermediate filaments

research Hair Keratin: Composition, Structure and Biogenesis

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