The importance of the neuro‐immuno‐cutaneous system on human skin equivalent design

The document discussed the neuro-immuno-cutaneous (NIC) system, highlighting the skin's role as a sensory organ and its connection to the immune and nervous systems. It emphasized the importance of cutaneous innervation and the release of neuropeptides like substance P, neuropeptide Y, and nerve growth factor in the inflammatory response. The interplay between cutaneous, neuronal, and immune cells was noted as crucial in conditions such as psoriasis, atopic dermatitis, and vitiligo. The study underscored the need for in vitro tissue models based on human skin equivalents to better understand these interactions and their implications for research and clinical applications.