TLDR K15 is a reliable marker for studying stem cells in dog hair follicle tumors.
This study investigated the expression of stem cell markers keratin 15 (K15) and nestin in 44 canine follicular tumours and 30 squamous cell carcinomas to understand their role in tumourigenesis. K15 was found to be a reliable marker for studying stem cells in hair follicle tumours, with strong expression in trichoblastomas and variable expression in tricholemmomas and trichoepitheliomas. In contrast, nestin was not an optimal marker due to its faint expression. The presence of hair follicle stem cells in the bulge region and the loss of K15 expression in squamous cell carcinomas suggested a potential role in the development and malignant transformation of these tumours.
36 citations
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April 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Canine hair follicles have stem cells similar to human hair follicles, useful for studying hair disorders.
28 citations
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March 2010 in “Histochemistry and Cell Biology” Different markers are found in stem cells of the scalp's hair follicle bulge and the surrounding skin.
37 citations
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October 2009 in “Veterinary Dermatology” 
62 citations
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35 citations
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61 citations
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54 citations
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18 citations
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January 2013 in “Veterinary Dermatology” K15 is a reliable marker for studying stem cells in dog hair follicle tumors.
6 citations
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March 2011 in “European Journal of Dermatology” 35 citations
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December 2008 in “PubMed” Trichilemmoma, BCC, and SCC tumors have different stem cell marker expressions.
276 citations
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January 2005 in “International review of cytology” 199 citations
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January 2004 in “The International Journal of Developmental Biology” Hair follicle growth and development are controlled by specific genes and molecular signals.
29 citations
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94 citations
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135 citations
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