Expression of the hair stem cell-specific marker nestin in epidermal and follicular tumors.

    December 2008 in “ PubMed ”
    Maho Kanoh, Yasuyuki Amoh, Yuichi Sato, Kensei Katsuoka
    TLDR Trichilemmoma, BCC, and SCC tumors have different stem cell marker expressions.
    This study investigated the expression of hair follicle stem cell markers nestin, K15, and CD34 in normal human skin and various tumors. It found that in normal skin, nestin and K15 were expressed in specific hair follicle regions, while CD34 was not. In tumors, nestin was present in trichilemmoma but absent in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). K15 was strongly expressed in BCC and weakly in trichilemmoma, with SCC showing partial K15 positivity. The findings suggested that trichilemmoma originates from nestin-positive/K15-positive/CD34-negative cells, BCC from nestin-negative/K15-positive/CD34-negative cells, and SCC from nestin-negative/K15-positive/CD34-negative keratinocytes.
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