Tannic Acid Accelerates Cutaneous Wound Healing in Rats Via Activation of the ERK 1/2 Signaling Pathways

    July 2019 in “Advances in wound care
    Yaqin Chen, Lvbo Tian, Fang Yang, Tong Wu, Renyong Jia, Yuanfeng Zou, Lizi Yin, Lixia Li, Chao He, Xiaoxia Liang, Gang Ye, Cheng Lu, Xu Song
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    TLDR Tannic acid helps wounds heal faster in rats by activating certain cell signals and reducing inflammation.
    The study from July 2019 demonstrated that tannic acid (TA) significantly promotes wound healing in rats by activating the ERK 1/2 signaling pathway. TA treatment resulted in faster wound closure, enhanced re-epithelialization, and increased hair follicle growth compared to untreated wounds. The study also found that TA reduced pro-inflammatory cytokines IL-1 and IL-6, while increasing the expression of growth factors such as bFGF, which are essential for healing. These findings suggest that TA has potential as a therapeutic agent for improving wound healing and hair follicle regeneration. The study involved 72 rats, providing a substantial sample size for the research conclusions.
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