TLDR A new imaging technique can observe stem cells in living mice without harming them.
The study demonstrated the use of high-resolution in-vivo multiphoton tomography to observe nestin-GFP expressing stem cells in the bulge of hair follicles in living mice. This non-invasive imaging technique allowed for the visualization of stem cells in their native environment without affecting their metabolism, reproduction, or behavior. The research highlighted the potential of hair follicle pluripotent stem cells, located in the bulge area and dermal papilla, to generate various cell types and participate in wound healing. The 3D imaging technique, utilizing two-photon induced fluorescence and second harmonic generation of collagen, successfully detected migrating stem cells within the skin, showcasing the method's capability for optical deep tissue sectioning.
January 2022 in “Journal of St. Marianna University” Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.
15 citations
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April 2014 in “Experimental Dermatology” Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.
6 citations
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March 2011 in “European Journal of Dermatology” Nestin-positive cells are important for hair follicle regeneration in alopecia areata.
321 citations
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December 2009 in “Journal of Dermatological Science” Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
32 citations
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August 2006 in “Archives of Dermatological Research” Dermal papilla cells can help regrow hair follicles.
January 2003 in “Chinese Journal of Reparative and Reconstructive Surgery” Dermal papilla cells can help form hair follicles and produce hair.
66 citations
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August 2001 in “Experimental Dermatology” Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
57 citations
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November 1998 in “Wound Repair and Regeneration” Hair papilla cells can create and regenerate hair bulbs under the right conditions.
