Stem Cell Therapy In Veterinary Dermatology

April 2013

Robert J. Harman

stem cell therapy mesenchymal stem cells alopecia bulge stem cell markers

Studysummary This chapter reviews the use and regulation of mesenchymal stem cells in veterinary dermatology, covering therapies for various skin conditions and highlighting future directions, but it reports no new findings. Our plain-language summary of this paper — not a Tressless recommendation.

The document discussed the application of stem cell therapy in veterinary dermatology, focusing on mesenchymal stem cells (MSCs). It covered various aspects, including the sources, identification, and mechanisms of action of MSCs. The therapy was explored for its potential in treating chronic nonhealing wounds, immune-mediated skin diseases, scar tissue, and alopecia in animals. The chapter also addressed the engineering of skin and the role of bulge stem cell markers in oncology. Additionally, it reviewed the regulatory framework by the US FDA concerning stem cell therapy in veterinary medicine and speculated on future advancements in the field.

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6 / 6 results

research Stem Cells and Alopecia: A Review of Pathogenesis

33 citations , April 2012 in “British Journal of Dermatology”

This review discusses the role of stem cells in alopecia pathogenesis, highlighting the differences between scarring and nonscarring types, and reports no new clinical results.

research Application of Mesenchymal Stem Cells Derived from Bone Marrow and Umbilical Cord in Human Hair Multiplication

41 citations , September 2010 in “Journal of dermatological science”

This study suggests that mesenchymal stem cell-induced dermal papilla-like tissues can generate new hair follicles in mice, indicating potential for developing hair cell therapy using stem cells.

research Canine Follicle Stem Cell Candidates Reside in the Bulge and Share Characteristic Features with Human Bulge Cells

36 citations , April 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that canine bulge-derived keratinocytes are highly proliferative and can reconstitute pilosebaceous structures, indicating their potential utility in studying human stem cell biology and hair disorders.

research Canine Hair-Follicle Keratinocytes Enriched With Bulge Cells Have the Highly Proliferative Characteristic of Stem Cells

37 citations , October 2009 in “Veterinary Dermatology”

This study identified and isolated highly proliferative canine keratinocytes in vitro, finding that follicular keratinocytes showed distinct proliferative capacity and marker expression indicative of putative epithelial stem cells.

research CD34 Glycoprotein Identifies Putative Stem Cells Located in the Isthmic Region of Canine Hair Follicles

21 citations , July 2006 in “Veterinary dermatology”

In this study, researchers reported that CD34 expression in the isthmic region of canine hair follicles suggests a potential stem cell compartment in this area.

research Cytokeratin 15 Expression in Trichoepitheliomas and a Subset of Basal Cell Carcinomas Suggests They Originate from Hair Follicle Stem Cells

133 citations , March 1999 in “Journal of Cutaneous Pathology”

This study found that keratin 15 expression in trichoepitheliomas and some basal cell carcinomas suggests a link to hair follicle stem cells in the bulge.