Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

    January 2007 in “ ˜The œYear book of dermatology ”
    B.H. Thiers
    Image of study
    TLDR Researchers successfully isolated and identified key stem cells in human hair follicles, which could help develop new skin and hair treatments.
    The study "Characterization and isolation of stem cell–enriched human hair follicle bulge cells" focused on identifying and isolating keratinocyte stem cells (KSCs) from the human hair follicle bulge, a key niche for these cells. Researchers used navigated laser capture microdissection and cDNA microarrays to analyze gene expression profiles, finding that genes inhibiting WNT and activin/bone morphogenic protein signaling were overrepresented in the bulge, while proliferation-related genes were underrepresented. They identified positive markers for bulge cells, including CD200, PHLDA1, follistatin, and frizzled homolog 1. CD200+ cells demonstrated high colony-forming efficiency, indicating successful enrichment of living human bulge stem cells. This work provided valuable insights into hair follicle biology and suggested potential for developing new therapies for skin and hair disorders.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 22 results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  44 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Please explain this Minoxidil phenomena

      in Minoxidil  60 upvotes 1 year ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

    Similar Research

    5 / 1000+ results