TLDR Skin stretching can improve vaccine delivery through hair follicles and boost immune response.
The study explores how transient skin stretching can enhance immune surveillance and vaccine delivery through hair follicles. It shows that skin stretching increases skin permeability and activates immune cells, leading to improved vaccine delivery without damaging the skin. This method enhances dendritic cell activity and results in stronger antibody responses compared to traditional intramuscular injections. The research suggests that mechanical stimuli can serve as a natural adjuvant for vaccines, although it also notes potential concerns about increased skin inflammation and allergen exposure. The study involved both human and mouse models, demonstrating improved delivery of a H1N1 vaccine antigen, and highlights the potential for needle-free vaccination strategies.
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,
August 2020 in “Chemical and Pharmaceutical Bulletin” Rubbing increases drug absorption through hair follicles.
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,
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,
January 2018 in “Bone Research” TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.
October 2020 in “Veterinary Dermatology” New treatments and diagnostic methods for various animal skin conditions showed promising results.
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,
January 2014 in “Springer eBooks” The book details skin conditions in older adults, their link to mental health, cancer treatment importance, hair loss remedies, and managing autoimmune and itchy skin.
