Skin-Derived Stem Cells for Wound Treatment Using Cultured Epidermal Autografts: Clinical Applications and Challenges

January 2018 in “ Stem Cells International ”

Inga Brockmann, Juliet Ehrenpfordt, Tabea Sturmheit, Matthias Brandenburger, Charli Kruse, Marietta Zille, Dorothee Rose, Johannes Boltze

skin-derived stem cells cultured epidermal autografts autologous transplantation mesh grafts Meek grafts stem cells progenitor cells wound healing transplantable tissue CEAs

TLDR Skin-derived stem cells show promise for improving wound healing and creating transplantable tissue.

The document reviewed the use of skin-derived stem cells for wound treatment, focusing on cultured epidermal autografts (CEAs) as a promising approach for extensive skin damage. It highlighted the limitations of existing autologous transplantation techniques like mesh and Meek grafts and emphasized the potential of stem and progenitor cells from the skin to enhance wound healing and generate transplantable tissue. The review also covered clinical trial activities and discussed the translational and clinical challenges in implementing these stem cell-based therapies.

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Research cited in this study

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research Stem Cells in the Skin

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Skin-Derived Stem Cells for Wound Treatment Using Cultured Epidermal Autografts: Clinical Applications and Challenges

Research cited in this study

research Bioengineering a 3D Integumentary Organ System from iPS Cells Using an In Vivo Transplantation Model

research Mechanisms Regulating Skin Immunity and Inflammation

research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

research Multipotent Nestin-Positive Stem Cells Reside in the Stroma of Human Eccrine and Apocrine Sweat Glands and Can Be Propagated Robustly In Vitro

research Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches

research Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and After Transplantation

research Hair Follicle Stem Cells: Walking the Maze

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

research Gene Expression Profiling Gets to the Root of Human Hair Follicle Stem Cells

research Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

research Successful Treatment of Chronic Leg Ulcers with Epidermal Equivalents Generated from Cultured Autologous Outer Root Sheath Cells

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