Shock: A Possible Presenting Manifestation of Autoimmune Polyendocrine Syndrome Type II

    January 2014 in “ Indian Journal of Critical Care Medicine ”
    Subodh Banzal, Abhishek Singhai
    TLDR Shock can be an early sign of Autoimmune Polyendocrine Syndrome Type II.
    A 38-year-old female presented in shock and was diagnosed with Autoimmune Polyendocrine Syndrome Type II (APS II), characterized by multiple endocrine insufficiencies including Addison's disease, hypothyroidism, and primary ovarian failure. Initial treatment with intravenous fluids, antibiotics, and dopamine was ineffective, but she improved with intravenous hydrocortisone and oral L-thyroxine. She was discharged after 1 week on a regimen of oral prednisolone, fludrocortisone, L-thyroxine, estrogen, and progesterone, which normalized her clinical condition and reduced skin pigmentation. The case highlighted the importance of early identification and treatment of associated autoimmune endocrine diseases.
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