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GlossaryAdrenal Insufficiency (Addison's disease)

occurs when adrenal glands produce insufficient cortisol and aldosterone

Adrenal Insufficiency, also known as adrenal failure or adrenal hypofunction, is a condition where the adrenal glands do not produce enough of certain hormones, particularly cortisol and sometimes aldosterone. This can lead to symptoms such as fatigue, muscle weakness, weight loss, low blood pressure, and skin changes. It can be caused by autoimmune disorders, infections, or other underlying health issues, and requires medical diagnosis and management.

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research Histopathologic Findings of Cutaneous Hyperpigmentation in Addison's Disease and Immunostain of the Melanocytic Population

9 citations , June 2017 in “The American journal of dermatopathology/American journal of dermatopathology”

The study found increased skin pigmentation and variable melanocyte density in a patient with Addison's disease.

research Oral Pigmentation as a Sign of Addison’s Disease: A Brief Reappraisal

13 citations , January 2009 in “The Open Dermatology Journal”

Oral pigmentation can be a sign of Addison's disease.

research Rapid Intravenous Administration of Corticotropin as a Test of Adrenocortical Insufficiency

17 citations , August 1967 in “JAMA”

The rapid corticotropin test is a quick and simple way to diagnose adrenal insufficiency.

research Mineral Deficiencies: A Root Cause for Reduced Longevity in Mammals

November 2020 in “IntechOpen eBooks”

Not getting enough minerals can lead to health problems and shorter lifespans.

research Diffuse Hair Loss in Addison Disease: A Reason for X-Linked Adrenoleukodystrophy Screening

3 citations , April 2012 in “Journal of the American Academy of Dermatology”

Men with Addison disease should be screened for X-linked adrenoleukodystrophy if they have hair loss.

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community Low cortisol it is due the fin

in Finasteride/Dutasteride 7 upvotes 8 months ago

The user has been taking 1mg finasteride daily for a year with no improvement in hair loss and reports low cortisol levels, sleep issues, and anxiety changes. The conversation includes discussions on the potential effects of finasteride on cortisol and neurosteroids, with suggestions to consult a doctor and consider other factors.

community Thoughts about ORAL ketoconazole? (pills)

in Ketoconazole 2 months ago

Oral ketoconazole is discussed as a potential hair loss treatment, but it poses significant health risks like liver damage and adrenal insufficiency. Users suggest safer alternatives like topical anti-androgens or spironolactone, emphasizing the importance of consulting a specialist.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.