Salmon Nasal Cartilage Proteoglycan Stimulates Hair Growth

October 2023 in “ Bioscience Biotechnology and Biochemistry ”

Akio Nakane, Shouhei Hirose, Noriaki Kawai, Naoki Fujimoto, Eriko Kondo, Krisana Asano

salmon nasal cartilage proteoglycan proteoglycan hair growth vesicular endothelial growth factor human follicle dermal papilla cells insulin growth factor-1 receptor

TLDR Salmon nasal cartilage proteoglycan may help hair grow.

The study explores the impact of salmon nasal cartilage proteoglycan (PG) on hair growth, revealing that PG stimulates hair growth by enhancing the production of vesicular endothelial growth factor (VEGF) in human follicle dermal papilla cells via insulin growth factor-1 receptor (IGF-1R) signaling. Conducted on male C3H/HeN mice, the research showed significant hair growth after 22 days of PG administration. The findings suggest PG's potential as a treatment for pattern hair loss and hair loss in chemotherapy patients, with possible indirect effects through gut microbiota improvement and direct effects on hair follicle cells, indicating potential for external application.

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