Case Report: Repigmentation and Complete Hair Regrowth in an 11-Year-Old Preadolescent with Alopecia Totalis Treated with a JAK Inhibitor

    July 2026 in “ Frontiers in Pediatrics ”
    Yanhong Jia, Xue Wang, Ying Liu … B Zhang
    Studysummary In this case study, an 11-year-old girl with severe alopecia areata experienced complete hair regrowth and unexpected white-to-black hair repigmentation after switching from baricitinib to ritlecitinib, suggesting that prolonged Janus kinase inhibition may aid both hair and pigment restoration in severe pediatric cases.
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    Research cited in this study 8

    1. Unexpected Extensive Hair Whitening Following Baricitinib Treatment for Alopecia Universalis: A Case Report and Mechanistic Insights Cureus · 2024
    2. Hair Regrowth in Alopecia Areata and Re-Pigmentation in Vitiligo in Response to Treatment: Commonalities and Differences Journal of the European Academy of Dermatology and Venereology · 2024
    3. Two Case Studies of Persistent White Hair Regrowth After Alopecia Areata Turning Pigmented Following Treatment Journal of Cosmetic Dermatology · 2024
    4. An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
    5. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    6. Marie Antoinette Syndrome Archives of Dermatology · 2009
    7. A Case of Widespread Non-Pigmented Hair Regrowth in Diffuse Alopecia Areata Australasian Journal of Dermatology · 2007
    8. Persistent Depigmented Regrowth After Alopecia Areata Journal of the American Academy of Dermatology · 2002