Progress in the Expression, Purification, and Characterization of Recombinant Collagen

    January 2026 in “ Bioengineering ”
    Youlin Deng, Jiyao Kang, Xiaoqun Duan, Fangyu Xing, Weiquan Xie, Dongjie Lei, Tingchun Wang, Guifeng Zhang
    TLDR Recombinant collagen is promising for biomaterials, pharmaceuticals, and skincare due to its benefits and potential improvements.
    Recombinant collagen, synthesized by expressing natural collagen sequences in specific hosts, offers advantages such as enhanced bioactivity, antioxidant activity, and low immunogenicity, making it valuable in biomaterials, pharmaceuticals, and skincare. This review examines various expression systems, including <i>Escherichia coli</i>, <i>Pichia pastoris</i>, plants, insect baculovirus, and mammalian cells, comparing their production efficiency, modification capabilities, and costs. It discusses purification techniques like chromatography and analyzes characterization methods for physicochemical and biological properties. The review identifies challenges such as reducing R&D costs and improving safety evaluations, proposing future directions for advancing recombinant collagen applications.
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