The Enzyme and Inhibitors of 4-Ene-3-Oxosteroid 5α-Oxidoreductase

    June 1995 in “ Steroids ”
    Xun Li, Cailin Chen, S. M. Singh, Fernand Labire
    Studysummary This review discusses biochemical studies on 5 alpha-reductase and its inhibitors, comparing IC50 and Ki values for various compounds, but reports no new experimental results.
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    Research cited in this study 7

    1. Azasteroids as Inhibitors of Testosterone 5α-Reductase in Mammalian Skin Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 1993
    2. Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase Journal of Medicinal Chemistry · 1993
    3. Structure of Human Type II 5 Alpha-Reductase Gene Endocrinology · 1992
    4. Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers The Journal of Clinical Endocrinology and Metabolism · 1990
    5. Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human Endocrinology · 1985
    6. Hormonal Control Of 5 Alpha-Reductase Activity In Hamster Sebaceous Glands Endocrinologia Japonica · 1982
    7. The Antiandrogenic Action of 4-Androsten-3-One-17β-Carboxylic Acid and Its Methyl Ester on Hamster Flank Organ Endocrinology · 1973

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