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    Biopolymer-Based Hydrogels for Wound Healing: Advances in Cellulose, Chitosan, Alginate, and Hyaluronic Acid from Design to Clinical Translation

    August 2026 in “ Pharmaceuticals ”
    Shery Jacob, Namitha Raichel Varkey, Sai H. S. Boddu … Anroop B. Nair
    Studysummary This review reports that biopolymer-based hydrogels show promise as wound dressings due to their biocompatibility, moisture retention, and ability to mimic the extracellular matrix, though challenges in mass production, safety, and clinical validation remain.
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    Research cited in this study 11

    1. Cellular and Molecular Mechanisms of Wound Repair: From Biology to Therapeutic Innovation Cells · 2025
    2. Advances in Hyaluronic Acid-Based Biomaterials: Applications in Cancer Therapy, Wound Healing, and Disease Management Journal of Materials Science Materials in Medicine · 2025
    3. Endogenous/Exogenous Stimuli-Responsive Smart Hydrogels for Diabetic Wound Healing Aggregate · 2024
    4. Hydrogel Crosslinking Modulates Macrophages, Fibroblasts, And Their Communication During Wound Healing Nature Communications · 2024
    5. In Vitro and In Vivo Evaluation of Chitosan/HPMC/Insulin Hydrogel for Wound Healing Applications Bioengineering · 2024
    6. Recent Advances in Biodegradable and Biocompatible Synthetic Polymers Used in Skin Wound Healing Materials · 2023
    7. Silk Fibroin-Gelatin Photo-Crosslinked 3D-Bioprinted Hydrogel with MOF-Methylene Blue Nanoparticles for Infected Wound Healing International Journal of Bioprinting · 2023
    8. Extracellular Vesicle-Loaded Hydrogels for Tissue Repair and Regeneration Materials Today Bio · 2022
    9. Alginate and Its Application to Tissue Engineering SN Applied Sciences · 2021
    10. Conditioned Media Derived from Mesenchymal Stem Cell Cultures: The Next Generation for Regenerative Medicine Journal of Tissue Engineering and Regenerative Medicine · 2019
    11. Cellular and Molecular Mechanisms of Repair in Acute and Chronic Wound Healing British Journal of Dermatology · 2015