An Isotope Dilution-Liquid Chromatography-Tandem Mass Spectrometry-Based Candidate Reference Measurement Procedure for the Quantification of 5-Alpha-Dihydrotestosterone in Human Serum and Plasma

    January 2026 in “ Clinical Chemistry and Laboratory Medicine (CCLM) ”
    L.L. Lewin, Michael Stadlmeier, Neeraj Singh … Judith Taibon
    Studysummary This study reported high analytical performance of an RMP for DHT quantification, with the ability to differentiate between 5α-DHT and 5β-DHT isomers, making it suitable for routine assay standardization and clinical sample evaluation.
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    Research cited in this study 4

    1. 5-Alpha Reductase Inhibitors Use in Prostatic Disease and Beyond Translational Andrology and Urology · 2023
    2. Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris American Journal of Clinical Dermatology · 2019
    3. Adverse Effects of 5α-Reductase Inhibitors: What Do We Know, Don't Know, and Need to Know? Reviews in Endocrine and Metabolic Disorders · 2015
    4. Clinical Biochemistry of Dihydrotestosterone Annals of Clinical Biochemistry · 2013