Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3

February 2007 in “ Cancer Research ”

Moammir Hasan Aziz, Herbert T. Manoharan, Ajit Kumar Verma

protein kinase Cε PKCε UV radiation squamous cell carcinoma Stat3 phosphorylation Stat3Ser727 Stat3Tyr705 transgenic mice photosensitizer UVR SCC

TLDR Protein Kinase Cε increases skin sensitivity to UV damage and skin cancer risk.

The study demonstrated that protein kinase Cε (PKCε) acted as an endogenous photosensitizer, increasing sensitivity to UV radiation-induced skin damage and squamous cell carcinoma (SCC) development. PKCε-overexpressing transgenic mice showed heightened sensitivity to UVR, leading to constitutive phosphorylation of Stat3 at Tyr705 and Ser727 residues, which was not observed in PKCδ-overexpressing mice. This phosphorylation was linked to increased expression of Stat3-regulated genes. The research identified PKCε as a Stat3Ser727 kinase, suggesting that PKCε-mediated phosphorylation of Stat3 at Ser727 was crucial for its transcriptional activity and played a significant role in the mechanism by which PKCε increased susceptibility to UVR-induced SCC.

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research Protein Kinase C Epsilon Signals Ultraviolet Light-induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism¶

28 citations , January 2005 in “Photochemistry and Photobiology”

Protein kinase C epsilon may increase skin cancer risk by affecting nearby cells.

research Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.

79 citations , October 2003 in “PubMed”

research Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.

99 citations , February 2000 in “PubMed”

Overexpressing PKCepsilon in mice reduces papillomas but increases carcinomas.

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