Potential roles of FGF5 as a candidate therapeutic target in prostate cancer.

January 2023 in “ PubMed ”

Mary M. Stangis, Avan N Colah, Dalton McLean, Richard B. Halberg, Lara S. Collier, William A. Ricke

TLDR Targeting FGF5 could help treat prostate cancer.

The document reviewed the potential role of Fibroblast growth factor 5 (FGF5) as a therapeutic target in prostate cancer (PCa) and benign prostatic hyperplasia (BPH). It highlighted that FGF5, which interacts with the Hedgehog signaling pathway during prostate development, might act as an oncogenic driver in cancer models, contributing to stemness, metastatic potential, and tumor proliferation. The review suggested that targeting FGF5 could be a promising strategy to alleviate the health burden of PCa and BPH, which significantly affect the quality of life and survival in the aging male population.

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