Polycystic ovary syndrome: etiology, pathogenesis and diagnosis
January 2011
in “Nature Reviews Endocrinology”
TLDR The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.
The document from 2011 reviews the etiology, pathogenesis, and diagnosis of Polycystic Ovary Syndrome (PCOS), a common endocrine disorder affecting up to 10% of women of reproductive age. It is characterized by symptoms such as hyperandrogenism, oligo-ovulation, and polycystic ovarian morphology, often accompanied by insulin resistance. The condition is linked to various morbidities, including infertility, obstetrical complications, type 2 diabetes, cardiovascular disease, and mood disorders. The document suggests that both genetic and environmental factors contribute to PCOS, with a heritability rate of 0.79 among Dutch twins and potential influences from prenatal testosterone exposure and lifestyle factors like weight gain. It also discusses the increased risk of mood disorders, endometrial abnormalities, and the evolutionary context of PCOS. Diagnosis involves confirming symptoms and excluding other conditions, while treatment is tailored to individual needs, focusing on symptom management and prevention of long-term complications. The document is a review and does not provide specific numbers of people studied.
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research Metabolic features of the reproductive phenotypes of polycystic ovary syndrome
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research Evidence-Based and Potential Benefits of Metformin in the Polycystic Ovary Syndrome: A Comprehensive Review
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research Polycystic Ovary Syndrome
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research Androgen Excess in Women: Experience with Over 1000 Consecutive Patients
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research Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
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research Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
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