Polyclonal origin and hair induction ability of dermal papillae in neonatal and adult mouse back skin

    June 2012 in “Developmental Biology
    Charlotte Collins, Kim B. Jensen, Elizabeth J. MacRae, William Mansfield, Fiona M. Watt
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    TLDR Dermal papillae cells, important for hair growth, come from multiple cell lines and can be formed by skin cells, regardless of their origin or hair cycle phase. These cells rarely divide, but their ability to shape tissue may contribute to their efficiency in inducing hair growth.
    In 2012, a study investigated the origins and hair growth induction ability of dermal papillae (DP), cells crucial for hair growth. The researchers found that DP cells are polyclonal, originating from multiple cell lines, and this was consistent regardless of how the DP formed. The study also discovered that adult dermal fibroblasts, skin cells, can contribute to DP during hair follicle formation, irrespective of their origin from skin in different phases of the hair cycle. The researchers suggested that fibroblasts might be induced to become DP cells through interactions with hair follicle epidermal cells. The study also indicated that DP formation might not rely on cell proliferation, as DP cells rarely divide. Instead, the hair growth induction efficiency of DP cells could be due to their morphogenetic capacity. The study also found that fibroblasts from various skin conditions could contribute to DP formation. The researchers concluded that further investigation into dermal cell heterogeneity was needed.
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