Polycystic Ovary Syndrome and Risks for COVID-19 Infection: A Comprehensive Review

February 2022 in “ Reviews in Endocrine and Metabolic Disorders ”

Sebastião Freitas de Medeiros, Márcia Marly Winck Yamamoto, Matheus Antônio Souto de Medeiros, Ana Karine Lin Winck Yamamoto, Bruna Barcelo Barbosa

polycystic ovary syndrome PCOS hyperandrogenism insulin resistance chronic inflammation obesity

Studysummary This review reports that women with polycystic ovary syndrome are at 28%–50% higher risk of SARS-CoV-2 infection, with increased rates of COVID-19-related hospitalization, morbidity, and mortality.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research The Immune System Response in COVID-19 Infection in Polycystic Ovary Syndrome

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research Sex Differences in COVID-19: The Role of Androgens in Disease Severity and Progression

121 citations , November 2020 in “Endocrine”

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research Clinical Symptoms of Hyperandrogenic Women Diagnosed with COVID-19

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This article is a discussion piece that examines the clinical symptoms of hyperandrogenic women with COVID-19, without reporting new research findings.

research Polycystic Ovary Syndrome (PCOS) and COVID-19: An Overlooked Female Patient Population at Potentially Higher Risk During the COVID-19 Pandemic

112 citations , July 2020 in “BMC Medicine”

This review discusses how overlapping risk factors in women with polycystic ovary syndrome may heighten their risk for severe COVID-19, advocating for integrated care approaches but provides no new clinical results.

research Are Sex Discordant Outcomes in COVID-19 Related to Sex Hormones?

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research Androgen Sensitivity Gateway to COVID-19 Disease Severity

123 citations , May 2020 in “Drug Development Research”

This article argues that androgen sensitivity could be a key factor in the severity of COVID-19, suggesting that trials with anti-androgen agents may be warranted.

research Coronavirus and Obesity: Could Insulin Resistance Mediate the Severity of COVID-19 Infection?

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A Preliminary Observation: Male Pattern Hair Loss Among Hospitalized COVID-19 Patients in Spain – A Potential Clue to the Role of Androgens in COVID-19 Severity

research A Preliminary Observation: Male Pattern Hair Loss Among Hospitalized COVID-19 Patients in Spain – A Potential Clue to the Role of Androgens in COVID-19 Severity

134 citations , April 2020 in “Journal of Cosmetic Dermatology”

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research What Does Androgenetic Alopecia Have to Do with COVID-19? An Insight into a Potential New Therapy

47 citations , April 2020 in “Dermatologic Therapy”

This letter discusses the potential connection between androgenetic alopecia and COVID-19, suggesting a possible new therapy, but it reports no new results.

Polycystic Ovary Syndrome, Androgen Excess, and the Risk of Nonalcoholic Fatty Liver Disease in Women: A Longitudinal Study Based on a United Kingdom Primary Care Database

research Polycystic Ovary Syndrome, Androgen Excess, and the Risk of Nonalcoholic Fatty Liver Disease in Women: A Longitudinal Study Based on a United Kingdom Primary Care Database

114 citations , March 2018 in “PLOS Medicine”

This study found that women with polycystic ovary syndrome have higher rates of nonalcoholic fatty liver disease, with androgen excess contributing to the risk.

research Vitamin D Receptor Polymorphisms and Polycystic Ovary Syndrome: A Systematic Review

36 citations , January 2017 in “Journal of Obstetrics and Gynaecology Research”

This review discusses the association between vitamin D receptor polymorphisms and polycystic ovary syndrome, noting the need for further research on their impact on the disorder's manifestations.

research Ovarian Hypertension: Polycystic Ovary Syndrome

60 citations , May 2011 in “Endocrinology and Metabolism Clinics of North America”

This article discusses the association between hypertension and polycystic ovary syndrome, highlighting the need for managing related risk factors, but reports no new clinical results.

research Polycystic Ovary Syndrome: Comprehensive Overview and Diagnostic Criteria

989 citations , August 2007 in “The Lancet”

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Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

research Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

1744 citations , August 2006 in “The Journal of Clinical Endocrinology and Metabolism”

This review discusses definitions of polycystic ovary syndrome and reports no new clinical results; the authors support using modified 1990 NIH criteria and acknowledge ongoing evolution as research advances.

research Androgen Excess in Women: Experience with Over 1000 Consecutive Patients

947 citations , February 2004 in “The Journal of Clinical Endocrinology and Metabolism”

In this study, polycystic ovary syndrome was the most prevalent cause of androgen excess, and suppressive hormonal therapy improved hirsutism, menstrual dysfunction, and acne in most patients, though side effects were common.

research The Pathophysiology of Polycystic Ovary Syndrome

249 citations , November 2003 in “Clinical endocrinology”

This review discusses the complex etiology of polycystic ovary syndrome (PCOS), highlighting its association with insulin resistance and hyperandrogenism, but reports no clinical findings; the authors suggest further investigation of the pathophysiological mechanisms.