Papulopustular Eruptions Associated With EGFR-Pathway-Related Targeted Therapies: Clinical Spectrum, Evidence Boundaries, Folliculocentric Inflammation, and Management Considerations

    July 2026 in “ Frontiers in Oncology ”
    Wei Li, Hui Xu
    Studysummary This mini review reports on papulopustular eruptions linked to classical EGFR inhibitors, MEK inhibitors, and amivantamab, highlighting distinct dermatologic toxicities in each treatment context and exploring underlying mechanisms and management strategies.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 7

    1. JAK-STAT1 as Therapeutic Target for EGFR Deficiency-Associated Inflammation and Scarring Alopecia EMBO Molecular Medicine · 2024
    2. Impact of Epidermal Growth Factor Receptor and Mitogen-Activated Kinase Inhibition on Hair Follicles: Partial Hair Follicle Immune Privilege Collapse and Excessive Interleukin-33 Secretion British Journal of Dermatology · 2024
    3. Epidermal Growth Factor Receptor/Mitogen-Activated Kinase Inhibitor Treatment Induces a Distinct Inflammatory Hair Follicle Response That Includes Collapse of Immune Privilege British Journal of Dermatology · 2024
    4. Folliculitis Decalvans-Like Alopecia During EGFR Inhibitors Treatment for Lung Cancer: A Case Series of 6 Patients Dermatology practical & conceptual · 2023
    5. EGFR Inhibitor-Induced Folliculitis Decalvans: A Case Series and Management Guidelines Anti-Cancer Drugs · 2023
    6. IL-36γ Drives Skin Toxicity Induced by EGFR/MEK Inhibition and Commensal Cutibacterium Acnes ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2019
    7. EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner iScience · 2019