Anti-CXCL4 Monoclonal Antibody Accelerates Telogen to Anagen Transition and Attenuates Apoptosis of the Hair Follicle in Mice

    June 2017 in “ Experimental and Therapeutic Medicine ”
    Wen Guan, Xiaolan Yu, Jingjing Li … Yu Ye
    Studysummary In a depilated mouse model, this study found that blocking CXCL4 activity with an anti-CXCL4 monoclonal antibody promoted hair growth by inducing an earlier anagen phase, delaying hair follicle regression, and altering expression of genes and proteins related to hair growth and cell proliferation.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on spandidos-publications.com →
    Discuss this study in the Community →

    Research cited in this study 8

    1. Treatment of MSCs with Wnt1a-Conditioned Medium Activates DP Cells and Promotes Hair Follicle Regrowth Scientific Reports · 2014
    2. Hair Growth-Promoting Activity of Hot Water Extract of Thuja Orientalis BMC Complementary and Alternative Medicine · 2013
    3. Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration Journal of Investigative Dermatology · 2012
    4. Prevalence of Androgenetic Alopecia in China: A Community-Based Study in Six Cities British Journal of Dermatology · 2010
    5. Eclipta Alba Extract With Potential For Hair Growth Promoting Activity Journal of Ethnopharmacology · 2009
    6. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    7. Splenic Eumelanin Differs From Hair Eumelanin in C57BL/6 Mice Acta Biochimica Polonica · 2005
    8. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001

    Related research 5

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. Expression of Matrix Metalloproteinases and Tissue Inhibitor of Matrix Metalloproteinases in the Hair Cycle Experimental and Therapeutic Medicine · 2016
    3. Dermal Papilla-Derived Wnt Ligands Are Required for Adult Hair Follicle Growth Journal of Investigative Dermatology · 2016
    4. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    5. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006