A Randomized Comparative Study Between Intralesional Vitamin D3 and Intralesional Triamcinolone Acetonide in the Treatment of Alopecia Areata

May 2025 in “ Journal of the Egyptian Womenʼs Dermatologic Society ”

Sarah Sayed El-Tawab, M. Abdelmoula, Khaled F. El Mulla

intralesional vitamin D3 triamcinolone acetonide alopecia areata hair regrowth steroids serum vitamin D levels vitamin D3 TAC

From the encyclopedia

Triamcinolone Acetonide →

Alopecia Areata →

autoimmune disorder causing patchy hair loss

cholecalciferol →

Studysummary This randomized controlled trial found that intralesional vitamin D3 was as effective and safe as intralesional triamcinolone acetonide for treating patchy alopecia areata on the scalp, with no significant influence from serum vitamin D levels on treatment response.

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Research cited in this study

14 / 14 results

research Intralesional Vitamin D3 in Treatment of Alopecia Areata: A Randomized Controlled Clinical Trial

7 citations , February 2022 in “Journal of Cosmetic Dermatology”

In this randomized controlled trial, intralesional vitamin D3 injections significantly improved localized alopecia areata symptoms compared to a saline placebo, with minimal and transient side effects, suggesting vitamin D3 as an effective treatment option without needing prior serum vitamin D level measurement.

research Role of Vitamin D in Hair Loss: A Short Review

14 citations , September 2021 in “Journal of Cosmetic Dermatology”

This review discusses vitamin D's role in hair follicle biology and its association with hair loss but reports no conclusive evidence for its effectiveness as a treatment, indicating the need for further studies.

Efficacy and Safety of Topical Calcipotriol 0.005% Versus Topical Clobetasol 0.05% in the Management of Alopecia Areata: An Intrasubject Pilot Study

research Efficacy and Safety of Topical Calcipotriol 0.005% Versus Topical Clobetasol 0.05% in the Management of Alopecia Areata: An Intrasubject Pilot Study

10 citations , April 2020 in “Dermatology and therapy”

In this study of 35 patients with scalp alopecia areata, calcipotriol ointment led to faster and greater hair regrowth than clobetasol, though differences were not statistically significant.

research New Aspects of Vitamin D Metabolism and Action: Addressing the Skin as Source and Target

378 citations , February 2020 in “Nature Reviews Endocrinology”

research Vitamin D and Alopecia Areata: Possible Roles in Pathogenesis and Potential Implications for Therapy

14 citations , January 2019 in “PubMed”

This review examines the potential roles of vitamin D in the pathogenesis of alopecia areata and suggests that vitamin D analogs like calcipotriol may have therapeutic potential.

research Trichoscopy of Alopecia Areata: An Update

89 citations , March 2018 in “The Journal of Dermatology”

This review presents various trichoscopic findings for diagnosing alopecia areata but reports no new clinical results, emphasizing that no single marker is pathognomonic and multiple features should be considered together.

research Correlation of Vitamin D and Vitamin D Receptor Expression in Patients with Alopecia Areata: A Clinical Paradigm

29 citations , December 2017 in “International Journal of Dermatology”

This study found that vitamin D deficiency in patients with alopecia areata was associated with greater disease severity and longer duration, but not with disease pattern or vitamin D receptor expression.

research Efficacy and Safety of Topical Calcipotriol in Management of Alopecia Areata: A Pilot Study

39 citations , January 2017 in “Dermatologic Therapy”

This study found that topical calcipotriol lotion resulted in hair regrowth in 59.1% of alopecia areata patients, with better response observed in those with lower serum vitamin D levels.

research Assessment of Serum 25-Hydroxyvitamin D Levels in Patients with Extensive/Recalcitrant Alopecia Areata Before and After PUVA and NB-UVB Therapy

3 citations , January 2015 in “Journal of the Egyptian Womenʼs Dermatologic Society”

research Alopecia Areata: Overview and Treatment Options

16 citations , January 2015 in “Current problems in dermatology”

This article reviews treatment options and psychological impacts of alopecia areata and reports no new clinical findings.

research Vitamin D Deficiency in Alopecia Areata

105 citations , March 2014 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, patients with alopecia areata were found to have significantly lower serum vitamin D levels compared to those with vitiligo and healthy individuals, with lower levels correlating with increased disease severity.

research Serum 25-Hydroxy Vitamin D3 Level in Egyptian Patients with Alopecia Areata

14 citations , January 2013 in “Journal of the Egyptian Women's Dermatologic Society /Journal of the Egyptian Women's Dermatologic Society”

research Dermoscopic Evaluation of Therapeutic Response to an Intralesional Corticosteroid in the Treatment of Alopecia Areata

35 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

This study found that intralesional triamcinolone acetonide is effective for treating localized patchy alopecia areata, with dermoscopy aiding in early detection of clinical response and adverse effects.

research Vitamin D Metabolism and Function in the Skin

185 citations , June 2011 in “Molecular and cellular endocrinology”

This review discusses the regulation and function of vitamin D and its receptor in skin cells, highlighting their roles in processes such as proliferation inhibition, differentiation, and innate immunity, but reports no new results.