Current Aspects of Skin Reparative Regeneration: A Modern Perspective on the Problem

December 2024 in “ Здобутки клінічної і експериментальної медицини ”

В. Д. Волошин, О. С. Волошин, М. І. Шанайда, Ю. С. Сморщок, М. В. Волошин

skin reparative regeneration stem cells nanotechnology skin substitutes selenium copper compounds mesenchymal stem cells adipose-derived stem cells angiogenesis inflammation processes immune response cell proliferation re-epithelialization bioengineered skin substitutes wound treatment fibrous scar development

Studysummary This study reviews current research on skin repair and regeneration, highlighting promising methods such as stem cell therapies, nanotechnology, and skin substitutes, which may enhance healing and resistance to environmental damage.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Extracellular Vesicle-Loaded Hydrogels for Tissue Repair and Regeneration

433 citations , December 2022 in “Materials Today Bio”

This review discusses the use of extracellular vesicle-loaded hydrogels in tissue regeneration and reports no clinical results; the authors highlight their potential and suggest future research directions.

research Hedgehog Signaling in Papillary Fibroblasts Is Essential for Hair Follicle Regeneration During Wound Healing

5 citations , December 2021 in “Journal of Investigative Dermatology”

This study observed that Hedgehog signaling in reticular and papillary fibroblast lineages plays different roles in wound repair and de novo hair follicle formation.

research Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts During Wound Healing

128 citations , August 2020 in “Cell stem cell”

In this study, researchers found that extrafollicular progenitors marked by Hic1 are the main contributors to reparative fibroblasts in wound repair, with potential to modulate healing outcomes through genetic and pharmacological interventions.

research Hopes and Limits of Adipose-Derived Stem Cells and Mesenchymal Stem Cells in Wound Healing

263 citations , February 2020 in “International journal of molecular sciences”

This paper discusses the potential roles of adipose tissue derived stem cells in skin regeneration and wound healing but emphasizes the need for further research on their effectiveness in clinical settings.

research Toward Understanding Scarless Skin Wound Healing and Pathological Scarring

113 citations , June 2019 in “F1000Research”

This review discusses the mechanisms of wound healing and excessive scarring, highlighting the importance of understanding these processes for developing new therapies to prevent fibrotic scarring in large skin wounds.

The Effect of Mesenchymal Stem Cells and Chitosan Gel on Full Thickness Skin Wound Healing in Albino Rats: Histological, Immunohistochemical and Fluorescent Study

research The Effect of Mesenchymal Stem Cells and Chitosan Gel on Full Thickness Skin Wound Healing in Albino Rats: Histological, Immunohistochemical and Fluorescent Study

23 citations , September 2015 in “PLOS ONE”

This study found that mesenchymal stem cells, especially when injected intradermally, significantly accelerated wound healing in rats compared to chitosan treatment.